Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3
comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
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https://doi.org/10.1007/s00424-018-2237-6 |
Metadata
Title
Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3Date
2018Publisher
SpringerISSN
0031-6768; 1432-2013Bibliographic citation
Sanchez-Andres, J.V., Malaisse, W.J. & Kojima, I. Pflugers Arch - Eur J Physiol (2018). https://doi.org/10.1007/s00424-018-2237-6Type
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/article/10.1007/s00424-018-2237-6Version
info:eu-repo/semantics/publishedVersionAbstract
Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells
was documented. The activation of this receptor by sweet-tasting sucralose mimics several ... [+]
Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells
was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of
D-glucose in the β-cells. The present study extends this analogy to the bioelectrical response of β-cells. In this respect, sucralose
was inefficient in the absence of D-glucose, but induced on occasion electrical activity in mouse β-cells exposed to low nonstimulatory concentrations of the hexose and potentiated, in a concentration-related manner, the response to stimulatory concentrations of D-glucose. These data indicate that sucralose, acting as an agonist of the TIR3 receptor, exerts an excitatory effect upon
pancreatic β-cell bioelectrical activity [-]
Is part of
Pflügers Archiv - European Journal of Physiology, 14 December 2018Rights
© Springer-Verlag GmbH Germany, part of Springer Nature 2018
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- MED_Articles [655]