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Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions

dc.contributor.authorSanchez Peris, Maria
dc.contributor.authorFalomir, Eva
dc.contributor.authorMurga, Juan
dc.contributor.authorCarda, Miguel
dc.contributor.authorMarco, J. Alberto
dc.date.accessioned2016-06-20T14:39:35Z
dc.date.available2016-06-20T14:39:35Z
dc.date.issued2016
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.urihttp://hdl.handle.net/10234/160929
dc.description.abstractA group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell line (HEK-293). 29 selected compounds have been investigated for their ability to inhibit the production of the vascular endothelial growth factor (VEGF). Subsequently, the capacity of the compounds to downregulate the expression of the VEGF, h-TERT and c-Myc genes, the two latter involved in the control of the activation of telomerase, has also been determined.ca_CA
dc.description.sponsorShipFinancial support has been granted to M.C. by the Ministerio de Economía y Competitividad of Spain (project CTQ2014- 52949-P), by the Consellería d´Empresa, Universitat i Ciencia de la Generalitat Valenciana (projects PROMETEO/2013/027 and ACOMP/2014/ 274) and by the University Jaume I (project PI- 1B2011-37). M. S.-P. thanks the University Jaume I for a predoctoral fellowship.ca_CA
dc.format.extent8 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfBioorganic & Medicinal Chemistry 24 (2016) 3108–3115ca_CA
dc.rights2016 Elsevier Ltd. All rights reserved.ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectBiphenyl derivativesca_CA
dc.subjectTelomeraseca_CA
dc.subjectVEGFca_CA
dc.subjectAntiangiogenesisca_CA
dc.subjecthTERTca_CA
dc.titleSynthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressionsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.bmc.2016.05.030
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0968089616303546ca_CA


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