Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions
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Altres documents de l'autoria: Sanchez Peris, Maria; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadades
Títol
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressionsData de publicació
2016Editor
ElsevierISSN
0968-0896; 1464-3391Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.sciencedirect.com/science/article/pii/S0968089616303546Paraules clau / Matèries
Resum
A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been
investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell
line (HEK-293). ... [+]
A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been
investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell
line (HEK-293). 29 selected compounds have been investigated for their ability to inhibit the production
of the vascular endothelial growth factor (VEGF). Subsequently, the capacity of the compounds to downregulate
the expression of the VEGF, h-TERT and c-Myc genes, the two latter involved in the control of the
activation of telomerase, has also been determined. [-]
Publicat a
Bioorganic & Medicinal Chemistry 24 (2016) 3108–3115Drets d'accés
2016 Elsevier Ltd. All rights reserved.
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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