Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions
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Otros documentos de la autoría: Sanchez Peris, Maria; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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Título
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressionsFecha de publicación
2016Editor
ElsevierISSN
0968-0896; 1464-3391Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0968089616303546Palabras clave / Materias
Resumen
A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been
investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell
line (HEK-293). ... [+]
A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been
investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell
line (HEK-293). 29 selected compounds have been investigated for their ability to inhibit the production
of the vascular endothelial growth factor (VEGF). Subsequently, the capacity of the compounds to downregulate
the expression of the VEGF, h-TERT and c-Myc genes, the two latter involved in the control of the
activation of telomerase, has also been determined. [-]
Publicado en
Bioorganic & Medicinal Chemistry 24 (2016) 3108–3115Derechos de acceso
2016 Elsevier Ltd. All rights reserved.
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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