The link between resting-state functional connectivity and cognition in MS patients
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Otros documentos de la autoría: Cruz Gómez, Álvaro Javier; Ventura Campos, Mercedes; Belenguer Benavides, Antonio; Avila, Cesar; Forn, Cristina
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Título
The link between resting-state functional connectivity and cognition in MS patientsAutoría
Fecha de publicación
2013Editor
SAGEISSN
1352-4585; 1477-0970Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://msj.sagepub.com/content/20/3/338.full.pdf+htmlPalabras clave / Materias
Resumen
Background/Objective: The objective of this paper is to explore differences in resting-state functional connectivity
between cognitively impaired and preserved multiple sclerosis (MS) patients.
Methods: Sixty MS ... [+]
Background/Objective: The objective of this paper is to explore differences in resting-state functional connectivity
between cognitively impaired and preserved multiple sclerosis (MS) patients.
Methods: Sixty MS patients and 18 controls were assessed with the Brief Repeatable Battery of Neuropsychological
Tests (BRB-N). A global Z score of the BRB-N was obtained and allowed us to classify MS patients as cognitively
impaired and cognitively preserved (n = 30 per group). Functional connectivity was assessed by independent component
analysis of resting-state networks (RSNs) related to cognition: the default mode network, left and right frontoparietal
and salience network. Between-group differences were evaluated and a regression analysis was performed to describe
relationships among cognitive status, functional connectivity and radiological variables.
Results: Compared to cognitively preserved patients and healthy controls, cognitively impaired patients showed a lesser
degree of functional connectivity in all RSNs explored. Cognitively preserved patients presented less connectivity than
the control group in the left frontoparietal network. Global Z scores were positively and negatively correlated with brain
parenchymal fraction and lesion volume, respectively.
Conclusion: Decreased cognitive performance is accompanied by reduced resting state functional connectivity and
directly related to brain damage. These results support the use of connectivity as a powerful tool to monitor and predict
cognitive impairment in MS patients. [-]
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Multiple Sclerosis Journal 2014, Vol. 20(3)Derechos de acceso
© The Author(s) 2013
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