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dc.contributor.authorCruz Gómez, Álvaro Javier
dc.contributor.authorVentura Campos, Noelia
dc.contributor.authorBelenguer Benavides, Antonio
dc.contributor.authorAvila, Cesar
dc.contributor.authorForn, Cristina
dc.date.accessioned2014-05-20T17:36:59Z
dc.date.available2014-05-20T17:36:59Z
dc.date.issued2013
dc.identifier.issn1352-4585
dc.identifier.issn1477-0970
dc.identifier.urihttp://hdl.handle.net/10234/92932
dc.description.abstractBackground/Objective: The objective of this paper is to explore differences in resting-state functional connectivity between cognitively impaired and preserved multiple sclerosis (MS) patients. Methods: Sixty MS patients and 18 controls were assessed with the Brief Repeatable Battery of Neuropsychological Tests (BRB-N). A global Z score of the BRB-N was obtained and allowed us to classify MS patients as cognitively impaired and cognitively preserved (n = 30 per group). Functional connectivity was assessed by independent component analysis of resting-state networks (RSNs) related to cognition: the default mode network, left and right frontoparietal and salience network. Between-group differences were evaluated and a regression analysis was performed to describe relationships among cognitive status, functional connectivity and radiological variables. Results: Compared to cognitively preserved patients and healthy controls, cognitively impaired patients showed a lesser degree of functional connectivity in all RSNs explored. Cognitively preserved patients presented less connectivity than the control group in the left frontoparietal network. Global Z scores were positively and negatively correlated with brain parenchymal fraction and lesion volume, respectively. Conclusion: Decreased cognitive performance is accompanied by reduced resting state functional connectivity and directly related to brain damage. These results support the use of connectivity as a powerful tool to monitor and predict cognitive impairment in MS patients.ca_CA
dc.format.extent11 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherSAGEca_CA
dc.relation.isPartOfMultiple Sclerosis Journal 2014, Vol. 20(3)ca_CA
dc.rights© The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.navca_CA
dc.subjectResting state functional connectivityca_CA
dc.subjectcognitive impairmentca_CA
dc.subjectdefault networkca_CA
dc.subjectright frontoparietal networkca_CA
dc.subjectleft frontoparietal networkca_CA
dc.titleThe link between resting-state functional connectivity and cognition in MS patientsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1177/1352458513495584
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://msj.sagepub.com/content/20/3/338.full.pdf+htmlca_CA


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