ListarFCA_Articles por tema "membrane proteins"
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Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold
Elsevier (2023-12-29)TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and metabolism, and is associated with pathologies like muscular dystrophy ... -
On the different sources of cooperativity in pH titrating sites of a membrane protein channel
EDP Sciences (2016)Cooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of different ...