Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation
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Otros documentos de la autoría: Salamone, John; Correa, Merce; Farrar, Andrew M.; Nunes, Eric J.; Collins, Lyndsey E.
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Título
Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivationFecha de publicación
2010Editor
Future MedicineISSN
1479-6708; 1748-6971Cita bibliográfica
Future Neurology (2010) Vol. 5, no. 3, p. 377-392Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.futuremedicine.com/doi/abs/10.2217/fnl.10.19Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Brain dopamine, particularly in the nucleus accumbens, has been implicated in activational aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce the tendency of rats to work for food, ... [+]
Brain dopamine, particularly in the nucleus accumbens, has been implicated in activational aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce the tendency of rats to work for food, and alter effort-related decision making, but leave aspects of food motivation such as appetite intact. Recent evidence indicates that the purine neuromodulator adenosine, largely through actions on adenosine A2A receptors, also participates in regulating effort-related processes. Adenosine A2A antagonists can reverse the effects of dopamine D2 antagonists on effort-related choice, and intra- accumbens injections of adenosine A2A agonists produce effects that are similar to those induced by accumbens dopamine depletion or antagonism. These studies have implications for the understanding and treatment of energy-related disorders such as anergia and fatigue in psychiatry and neurology. [-]
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