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Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues
dc.contributor.author | Sanchis-Segura, Carla | |
dc.contributor.author | Jancic, Dragana | |
dc.contributor.author | Jiménez Minchán, María | |
dc.contributor.author | Barco, Ángel | |
dc.date.accessioned | 2011-08-22T11:09:35Z | |
dc.date.available | 2011-08-22T11:09:35Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Sanchis-Segura C, Jancic D, Jimenez-Minchan M and Barco A (2009). Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues. Front. Behav. Neurosci. 3:30. | |
dc.identifier.issn | 1662-5153 | |
dc.identifier.uri | http://hdl.handle.net/10234/27044 | |
dc.description.abstract | To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues. | |
dc.format.extent | 7 p. | |
dc.language.iso | eng | |
dc.publisher | Frontiers Research Foundation | |
dc.relation.isPartOf | Frontiers in behavioral neuroscience, vol. 3 (Sept. 2009) | |
dc.rights | © Frontiers Research Foundation | |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | CREB | |
dc.subject | Morphine | |
dc.subject | Addiction | |
dc.subject | Place preference | |
dc.subject | Striatum | |
dc.subject | Addicció | |
dc.subject.other | Morfina | |
dc.title | Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues | |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | http://dx.doi.org/10.3389/neuro.08.030.2009 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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