Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues
Visualitza/
Impacte
Scholar |
Altres documents de l'autoria: Sanchis-Segura, Carla; Jancic, Dragana; Jiménez Minchán, María; Barco, Ángel
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadades
Títol
Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cuesData de publicació
2009Editor
Frontiers Research FoundationISSN
1662-5153Cita bibliogràfica
Sanchis-Segura C, Jancic D, Jimenez-Minchan M and Barco A (2009). Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues. Front. Behav. Neurosci. 3:30.Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB ... [+]
To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues. [-]
Publicat a
Frontiers in behavioral neuroscience, vol. 3 (Sept. 2009)Drets d'accés
© Frontiers Research Foundation
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
Apareix a les col.leccions
- PSB_Articles [1310]