An easy and green assay to determine albendazole and ivermectin in veterinary preparations by micellar liquid chromatography
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Otros documentos de la autoría: Pawar, Rajendra-Prasad; Sharma, Dr Girraj; Durgbanshi, Abhilasha; Bose, Devasish; Vives-Peris, Vicente; Roca Genovés, Pascual; Carda-Broch, Samuel
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Título
An easy and green assay to determine albendazole and ivermectin in veterinary preparations by micellar liquid chromatographyAutoría
Fecha de publicación
2023-01-25Editor
WileyCita bibliográfica
PAWAR, Rajendra‐Prasad, et al. An easy and green assay to determine albendazole and ivermectin in veterinary preparations by micellar liquid chromatography. Electrophoresis, 2024, 45, 3-4, p. 2212-217Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
A procedure to determine albendazole and ivermectin in veterinary formulations, like tablet, bolus, oral suspensions, and injections by micellar liquid chromatography, has been developed. Sample preparation was a batch ... [+]
A procedure to determine albendazole and ivermectin in veterinary formulations, like tablet, bolus, oral suspensions, and injections by micellar liquid chromatography, has been developed. Sample preparation was a batch solid-to-liquid extraction in mobile phase, consisting of a stirring step (15 min), followed by ultrasonication (15 min) and filtration of the obtained supernatant, to reach a target concentration of 2 mg/L for both analytes. Using a mobile phase of 0.15 M sodium dodecyl sulfate—6% 1-pentanol buffered at pH 3 with a 0.01 M phosphate salt, running at 1 mL/min through a C18 column, both drugs were resolved in less than 10 min. Absorbance detection wavelength was 292 nm. Procedure was validated by the guidelines of the International Council on Harmonization in terms of specificity, calibration range (0.025–5 mg/L), trueness (97.8%–102.6%), precision (<2.2%), and system suitability. The method was found easy-to-handle, low cost, safe, green, and with high sample-throughput, thus useful for routine analysis. Therefore, it represents a valuable alternative for quality control of veterinary formulations. It was applied to samples of veterinary formulations purchased from local chemists and veterinarians, and label claims were inside the acceptance criteria (95%–105%). [-]
Publicado en
Electrophoresis, 2024, 45, 3-4Entidad financiadora
Ministerio de Ciencia, Innovación y Universidades (Spain) | Ministry of Science and Technology, Government of India | MCIN/AEI/10.13039/501100011033 | Projekt DEAL
Código del proyecto o subvención
PID2019-106708GB-I00 | Sl.No.64
Título del proyecto o subvención
Open Access funding
Derechos de acceso
© 2023 The Authors. Electrophoresis published by Wiley-VCH GmbH.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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