Oil-In-Water Microemulsion Liquid Chromatography
Impacto
Scholar |
Otros documentos de la autoría: Peris García, Ester; Pankajkumar-Patel, N.; Ruiz-Angel, María José; Carda-Broch, Samuel; García-Alvarez-Coque, María Celia
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https://doi.org/10.1080/15422119.2018.1524386 |
Metadatos
Título
Oil-In-Water Microemulsion Liquid ChromatographyAutoría
Fecha de publicación
2020Editor
Taylor and FrancisISSN
1542-2119; 1542-2127Cita bibliográfica
PERIS-GARCÍA, Ester, et al. Oil-in-water microemulsion liquid chromatography. Separation & Purification Reviews, 2020, vol. 49, núm. 2, p. 89-111Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.tandfonline.com/doi/abs/10.1080/15422119.2018.1524386Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Oil-in-water microemulsions (O/W MEs) are obtained spontaneously by mixing two immiscible liquids (water and oil) in the presence of a surfactant. A co-surfactant is also often needed for ME stabilization. The surfactant ... [+]
Oil-in-water microemulsions (O/W MEs) are obtained spontaneously by mixing two immiscible liquids (water and oil) in the presence of a surfactant. A co-surfactant is also often needed for ME stabilization. The surfactant provides a microstructure with a definite boundary between oil and water phases. O/W MEs are used as mobile phases in a chromatographic mode known as microemulsion liquid chromatography (MELC). One of the main appeals of O/W MEs is the ability to solubilize compounds in a wide range of polarities, from polar to hydrophobic. The solubilizing effect on sample matrices is also noteworthy. The dual behavior of O/W MEs offers unique selectivity and reduced retention times, with equivalent or superior efficiency compared to conventional reversed-phase liquid chromatography, giving rise to successful isocratic separations. The complex nature of MELC mobile phases allows numerous composition options (type and concentration of surfactant, oil and co-surfactant) that lead to good separation performance, when compared to other chromatographic modes. A thorough revision of the main topics concerning MELC, such as nature and properties of O/W MEs, mechanism of retention, selectivity and diverse aspects related to the experimental practice for the determination of drugs in clinical and pharmaceutical samples, is presented. [-]
Publicado en
Separation & Purification Reviews, 2020, vol. 49, núm. 2, p. 89-111Entidad financiadora
Universitat de València | Ministerio de Economía, Industria y Competitividad (MINECO, España) | European Regional Development Fund (FEDER) | Generalitat Valenciana
Código del proyecto o subvención
UV INV-PREDOC16F1-384313 | CTQ2016-75644-P | PROMETEO /2016/128
Derechos de acceso
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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