The Cerebellum on Cocaine
comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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INVESTIGACIONMetadata
Title
The Cerebellum on CocaineDate
2020-10-21Publisher
Frontiers MediaISSN
1662-5137Bibliographic citation
Miquel M, Gil-Miravet I and Guarque-Chabrera J (2020) The Cerebellum on Cocaine. Front. Syst. Neurosci. 14:586574. doi: 10.3389/fnsys.2020.586574Type
info:eu-repo/semantics/articlePublisher version
https://www.frontiersin.org/articles/10.3389/fnsys.2020.586574/fullVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
The traditional cerebellum’s role has been linked to the high computational demands
for sensorimotor control. However, several findings have pointed to its involvement in
executive and emotional functions in the ... [+]
The traditional cerebellum’s role has been linked to the high computational demands
for sensorimotor control. However, several findings have pointed to its involvement in
executive and emotional functions in the last decades. First in 2009 and then, in 2016,
we raised why we should consider the cerebellum when thinking about drug addiction.
A decade later, mounting evidence strongly suggests the cerebellar involvement in this
disorder. Nevertheless, direct evidence is still partial and related mainly to drug-induced
reward memory, but recent results about cerebellar functions may provide new insights
into its role in addiction. The present review does not intend to be a compelling revision
on available findings, as we did in the two previous reviews. This minireview focuses on
specific findings of the cerebellum’s role in drug-related reward memories and the way
ahead for future research. The results discussed here provide grounds for involving the
cerebellar cortex’s apical region in regulating behavior driven by drug-cue associations.
They also suggest that the cerebellar cortex dysfunction may facilitate drug-induced
learning by increasing glutamatergic output from the deep cerebellar nucleus (DCN) to
the ventral tegmental area (VTA) and neural activity in its projecting areas. [-]
Is part of
Front. Syst. Neurosci. 14:586574Investigation project
Ministerio de Ciencia e Innovación, Grant/Award No. PGC2018-095980-B-I00; Ministerio de Economía y Competitividad (MINECO), Grant/Award Number: PSI2015-68600-P; Plan Nacional de Drogas 2017, Grant/Award No. PND-132400; Universitat Jaume I (UJI), Grant/Award No. 14I307.01/1; Universitat Jaume I, PREDOC2014/11.Rights
info:eu-repo/semantics/openAccess
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