Listar por autoría "715d8702-8cb5-4d22-9736-a063feb7ca48"
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A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity
MIQUEL, MARTA; Nicola, Saleem; Gil-Miravet, Isis; Guarque-Chabrera, Julian; Sanchez-Hernandez, Aitor Frontiers Media (2019-05)Growing evidence associates cerebellar abnormalities with several neuropsychiatric disorders in which compulsive symptomatology and impulsivity are part of the disease pattern. Symptomatology of autism, addiction, ... -
Cerebellar perineuronal nets in cocaine-induced pavlovian memory: Site matters
Carbó Gas, María; Moreno Rius, Josep; Guarque-Chabrera, Julian; Vázquez Sanromán, Dolores; Gil-Miravet, Isis; Carulli, Daniela; Hoebeek, Freek; De Zeeuw, Chris; Sanchis-Segura, Carla; MIQUEL, MARTA Elsevier (2017-07-14)One of the key mechanisms for the stabilization of synaptic changes near the end of critical periods for experience-dependent plasticity is the formation of specific lattice extracellular matrix structures called perineuronal ... -
Cocaine-Induced Preference Conditioning: a Machine Vision Perspective
Traver Roig, Vicente Javier; Pla, Filiberto; MIQUEL, MARTA; Carbó Gas, María; Gil-Miravet, Isis; Guarque-Chabrera, Julian Springer (2018)Existing work on drug-induced synaptic changes has shown that the expression of perineuronal nets (PNNs) at the cerebellar cortex can be regulated by cocaine-related memory. However, these studies on animals have mostly ... -
Mapping cFos expression after cerebellar and medial prefrontal deactivations in rats trained to acquire cocaine-induced preference conditioning
Gil-Miravet, Isis; Guarque-Chabrera, Julian; Musoles Lleó, Juan Luis; Olucha-Bordonau, Francisco E; MIQUEL, MARTA Mediterranean Neuroscience Society (2017-06) -
Neural correlates of cocaine-induced conditioned place preference in the posterior cerebellar cortex
Rodríguez Borillo, Olga; Roselló-Jiménez, Lorena; Guarque-Chabrera, Julian; Palau-Batet, María; Gil-Miravet, Isis; Pastor Medall, Raúl; MIQUEL, MARTA; Font Hurtado, Laura Frontiers Media (2023)Introduction: Addictive drugs are potent neuropharmacological agents capable of inducing long-lasting changes in learning and memory neurocircuitry. With repeated use, contexts and cues associated with consumption can ... -
Plasticity in the infralimbic cortex after a lesion of the dorsal posterior cerebellum: an inhibitory pathway for drug-dependent memories
Guarque-Chabrera, Julian Universitat Jaume I (2016-09-22)Addiction could be considered the result of pathological learning. Drug-associated cues become strong conditioned stimuli that create drug-related memories which promote drug seeking leading to relapse. Both, the ... -
Role of Perineuronal nets in the cerebellar cortex in cocaine-induced conditioned preference, extinction, and reinstatement
Guarque-Chabrera, Julian; Sanchez-Hernandez, Aitor; Ibáñez-Marín, Patricia; Melchor Eixea, Ignasi; MIQUEL, MARTA Elsevier Ltd (2022-08-17)Perineuronal nets (PNNs) are cartilage-like structures of extracellular matrix molecules that enwrap in a net-like manner the cell-body and proximal dendrites of special subsets of neurons. PNNs stabilize their incoming ... -
The Cerebellum on Cocaine
MIQUEL, MARTA; Gil-Miravet, Isis; Guarque-Chabrera, Julian Frontiers Media (2020-10-21)The traditional cerebellum’s role has been linked to the high computational demands for sensorimotor control. However, several findings have pointed to its involvement in executive and emotional functions in the last ... -
The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortex
Gil-Miravet, Isis; Guarque-Chabrera, Julian; Carbó Gas, María; Olucha-Bordonau, Francisco E; MIQUEL, MARTA John Wiley (2018-10-02)Drug-induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments with drug availability. Drug-related memory depends on persistent changes in dopamine-glutamate ... -
Time-dependent regulation of perineuronal nets in the cerebellar cortex during abstinence of cocaine-self administration
Sanchez-Hernandez, Aitor; Nicolas, Celine; Gil-Miravet, Isis; Guarque-Chabrera, Julian; Solinas, Marcello; MIQUEL, MARTA Springer (2021-01-03)Rationale The probability of structural remodeling in brain circuits may be modulated by molecules of perineuronal nets (PNNs) that restrict neuronal plasticity to stabilize circuits. Animal research demonstrates that ... -
When the front fails, the rear wins : cerebellar correlates of prefrontal dysfunction in cocaine-induced memory in male rats
Guarque-Chabrera, Julian; Gil-Miravet, Isis; Olucha-Bordonau, Francisco E; Melchor Eixea, Ignasi; MIQUEL, MARTA Elsevier ScienceDirect (2021-08-18)Reciprocal pathways connecting the cerebellum to the prefrontal cortex provide a biological and functional substrate to modulate cognitive functions. Dysfunction of both medial prefrontal cortex (mPFC) and cerebellum ...