Individual differences in running wheel performance are related to preferences for active reinforcers: the role of Nucleus Accumbens CDNF.
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Título
Individual differences in running wheel performance are related to preferences for active reinforcers: the role of Nucleus Accumbens CDNF.Autoría
Tutor/Supervisor; Universidad.Departamento
Correa Sanz, Mercè; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia.Fecha de publicación
2019-07-25Editor
Universitat Jaume IResumen
Exercise has been demonstrated to have a positive impact on psychological well-being
and mental health. Nucleus Accumbens (Nacb) dopamine (DA) has been implicated in
regulating the energizing component of motivated ... [+]
Exercise has been demonstrated to have a positive impact on psychological well-being
and mental health. Nucleus Accumbens (Nacb) dopamine (DA) has been implicated in
regulating the energizing component of motivated behavior, including effort-related
decision making, both in humans and rodents. It has been shown in rats that selection
of effortful operant options correlated with changes in DA related markers in Nacb. In
addition, exercise seems to prevent or help to improve motivational symptoms such as
fatigue and anergia. In the present study, we evaluated the relationship between
individual differences in endurance on a voluntary running wheel (RW), and differences
in Nacb parameters related to DA in adult male CD1 mice. Performance was evaluated
during 2 hours per day, 5 days a week during 4 weeks. Mice were selected based on the
second hour performance as high runners (HR, first quartile) and low runners (LR, forth
quartile). Behavioral phenotyping was performed before animals started training. Thus,
mice were evaluated in paradigms of anxiety, sociability and novelty induced
exploration in an open field. After training, animals were assessed in a T-maze RW task
in which rodents can chose between RW vs. sedentary activities such as consuming
sucrose or sniffing a neutral odor. HR spent significantly more time in the RW, and less
time in contact with the sedentary reinforcers (sucrose and odor) compared to LR. HR
also were indifferent to social stimuli compared to LR, but there were no differences in
other behaviors. Cerebral dopamine neurotrophic factor (CDNF) in Nacb was higher
among HR. These results suggest that differences in basal levels of voluntary exercise
increase predisposition to choose more active reinforcers that require high levels of
activation and effort, and indicate that differences in neurotrophic factors can sustain
differences in DA function. [-]
Palabras clave / Materias
Descripción
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2018/2019.
Tipo de documento
info:eu-repo/semantics/masterThesisDerechos de acceso
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