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Differences between male and female mice in behavioral activation and effort-related decision making
Martínez Verdú, Andrea Universitat Jaume I (2018-06-25) -
Efecto de la modulación dopaminérgica en la preferencia por reforzadores activos en ratones con una mutación en el factor de transcripción Pitx3
Verdejo-Penyarrocha, Mireia; Martínez-Verdú, Andrea; Olivares-García, Régulo; Matas-Navarro, Paula; Carratalá-Ros, Carla Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2022)La conducta motivada está caracterizada por altos niveles de activación, vigor y persistencia. La dopamina del núcleo accumbens (nacb) está implicada en regular este componente energizante de la motivación, incluida la ... -
Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice : sex-dependent response to antidepressant drugs with SERT and DAT blocker profiles
Carratalá Ros, Carla; Martínez‑Verdú, Andrea; Olivares-García, Régulo; Salamone, John; Correa, Merce Springer Nature (2023-07-05)Background ; Depression is a disorder twice as common in women than in men. There are sex differences in the symptomatology and treatment response to this disorder. Impairments in behavioral activation (i.e. anergia, ... -
Energizing effects of bupropion on effortful behaviors in mice under positive and negative test conditions: modulation of DARPP-32 phosphorylation patterns
Carratalá-Ros, Carla; Olivares-García, Régulo; Martínez-Verdú, Andrea; Arias-Sandoval, Edgar; Salamone, John; Correa, Merce Springer (2021-09-09)Motivational symptoms such as anergia, fatigue, and reduced exertion of effort are seen in depressed people. To model this, nucleus accumbens (Nacb) dopamine (DA) depletions are used to induce a low-effort bias in rodents ... -
Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion
Carratalá-Ros, Carla; López Cruz, Laura; Martínez Verdú, Andrea; Olivares-García, Régulo; Salamone, John; Correa, Merce Frontiers Media (2021)Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low ... -
Individual differences in running wheel performance are related to preferences for active reinforcers: the role of Nucleus Accumbens CDNF.
Martínez Verdú, Andrea Universitat Jaume I (2019-07-25)Exercise has been demonstrated to have a positive impact on psychological well-being and mental health. Nucleus Accumbens (Nacb) dopamine (DA) has been implicated in regulating the energizing component of motivated ... -
Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia
Carratalá-Ros, Carla; López Cruz, Laura; San Miguel Segura, Noemí; Ibáñez-Marín, Patricia; Martínez Verdú, Andrea; Salamone, John; Correa, Merce Frontiers Media (2020-01-30)Physical activities can have intrinsic motivational or reinforcing properties. The choice to engage in voluntary physical activity is undertaken in relation to the selection of other alternatives, such as sedentary ... -
Sex and age differences in mice models of effort-based decision-making and anergia in depression : the role of dopamine, and cerebral-dopamine-neurotrophic-factor
Matas-Navarro, Paula; Carratalá Ros, Carla; Olivares-García, Régulo; Martínez-Verdú, Andrea; Salamone, John; Correa, Merce Springer Nature (2023-08-18)Mesolimbic dopamine (DA) regulates vigor in motivated behavior. While previous results have mainly been performed in male rodents, the present studies compared CD1 male and female mice in effort-based decision-making tests ...