Pup-derived stimulation induces increased response to PRL in the female mouse brain: implications for motivated maternal behaviour
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Título
Pup-derived stimulation induces increased response to PRL in the female mouse brain: implications for motivated maternal behaviourAutoría
Tutor/Supervisor; Universidad.Departamento
Salais López, Hugo; Universitat Jaume I. Unitat Predepartamental de MedicinaFecha de publicación
2018-07-24Editor
Universitat Jaume IResumen
Maternal behaviours are expressed by the mother to guarantee the survival of her offspring.
The expression of these behaviours requires a high motivation towards pups, known as
maternal motivation. In the mouse, it ... [+]
Maternal behaviours are expressed by the mother to guarantee the survival of her offspring.
The expression of these behaviours requires a high motivation towards pups, known as
maternal motivation. In the mouse, it is unclear whether the onset of motivated maternal
behaviour depends on endocrine signals of motherhood (among which the hormone prolactin
stands out) or pup-derived stimuli. We base this work on previous studies of our lab
demonstrating that pup-sensitised females (godmothers) showed an increase in maternal
motivation towards pups as a result of prolonged pup exposure. The aim of this study was to
investigate, in the same set of females (dams, godmothers and virgins), the interaction between
pup-derived stimuli and prolactin in the observed increase in maternal motivation. We analysed
the levels of prolactin signalling in 13 selected brain nuclei related to maternal behaviour
regulation, by means of the immunohistochemmical detection of phosphorylated STAT5
(element of the major signalling pathway of the prolactin receptor). This work found evidence
that in most of the analysed brain regions (the CeM, MePD, LSV, AC/ADP, MPOM, Pa, PIL
and LPAG), pSTAT5-immunoreactivity (measure of lactogenic signalling) increased
significantly with motherhood. Moreover, godmothers showed increased PRL signalling as
compared to virgins in some key brain regions in maternal behaviour regulation, specifically
the MPOM and the PIL. This suggests that pup-derived stimuli are exerting a sensitisation to
prolactin in these nuclei. This might be at the base of the increase in maternal motivation
observed in godmothers. This work discusses the putative mechanisms underlying this process [-]
Palabras clave / Materias
Descripción
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2017/2018
Tipo de documento
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