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dc.contributor.authorHontana Requena, Mireia
dc.contributor.otherSalais López, Hugo; Universitat Jaume I. Unitat Predepartamental de Medicina
dc.date.accessioned2018-12-14T12:49:59Z
dc.date.available2018-12-14T12:49:59Z
dc.date.issued2018-07-24
dc.identifier.urihttp://hdl.handle.net/10234/178137
dc.descriptionTreball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2017/2018ca_CA
dc.description.abstractMaternal behaviours are expressed by the mother to guarantee the survival of her offspring. The expression of these behaviours requires a high motivation towards pups, known as maternal motivation. In the mouse, it is unclear whether the onset of motivated maternal behaviour depends on endocrine signals of motherhood (among which the hormone prolactin stands out) or pup-derived stimuli. We base this work on previous studies of our lab demonstrating that pup-sensitised females (godmothers) showed an increase in maternal motivation towards pups as a result of prolonged pup exposure. The aim of this study was to investigate, in the same set of females (dams, godmothers and virgins), the interaction between pup-derived stimuli and prolactin in the observed increase in maternal motivation. We analysed the levels of prolactin signalling in 13 selected brain nuclei related to maternal behaviour regulation, by means of the immunohistochemmical detection of phosphorylated STAT5 (element of the major signalling pathway of the prolactin receptor). This work found evidence that in most of the analysed brain regions (the CeM, MePD, LSV, AC/ADP, MPOM, Pa, PIL and LPAG), pSTAT5-immunoreactivity (measure of lactogenic signalling) increased significantly with motherhood. Moreover, godmothers showed increased PRL signalling as compared to virgins in some key brain regions in maternal behaviour regulation, specifically the MPOM and the PIL. This suggests that pup-derived stimuli are exerting a sensitisation to prolactin in these nuclei. This might be at the base of the increase in maternal motivation observed in godmothers. This work discusses the putative mechanisms underlying this processca_CA
dc.format.extent33 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherUniversitat Jaume Ica_CA
dc.rights.urihttp://rightsstatements.org/vocab/CNE/1.0/*
dc.subjectMàster Universitari en Investigació en Cervell i Conductaca_CA
dc.subjectMáster universitario en Investigación en Cerebro y Conductaca_CA
dc.subjectMaster's Degree in Research on the Brain and Behaviourca_CA
dc.subjectMaternal behaviourca_CA
dc.subjectProlactinca_CA
dc.subjectNeuroendocrinologyca_CA
dc.subjectMaternal motivationca_CA
dc.subjectSociosexual brainca_CA
dc.subjectMaternal sensitisationca_CA
dc.titlePup-derived stimulation induces increased response to PRL in the female mouse brain: implications for motivated maternal behaviourca_CA
dc.typeinfo:eu-repo/semantics/masterThesisca_CA
dc.educationLevelEstudios de Postgradoca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA


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