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Pup-derived stimulation induces increased response to PRL in the female mouse brain: implications for motivated maternal behaviour
dc.contributor.author | Hontana Requena, Mireia | |
dc.contributor.other | Salais López, Hugo; Universitat Jaume I. Unitat Predepartamental de Medicina | |
dc.date.accessioned | 2018-12-14T12:49:59Z | |
dc.date.available | 2018-12-14T12:49:59Z | |
dc.date.issued | 2018-07-24 | |
dc.identifier.uri | http://hdl.handle.net/10234/178137 | |
dc.description | Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2017/2018 | ca_CA |
dc.description.abstract | Maternal behaviours are expressed by the mother to guarantee the survival of her offspring. The expression of these behaviours requires a high motivation towards pups, known as maternal motivation. In the mouse, it is unclear whether the onset of motivated maternal behaviour depends on endocrine signals of motherhood (among which the hormone prolactin stands out) or pup-derived stimuli. We base this work on previous studies of our lab demonstrating that pup-sensitised females (godmothers) showed an increase in maternal motivation towards pups as a result of prolonged pup exposure. The aim of this study was to investigate, in the same set of females (dams, godmothers and virgins), the interaction between pup-derived stimuli and prolactin in the observed increase in maternal motivation. We analysed the levels of prolactin signalling in 13 selected brain nuclei related to maternal behaviour regulation, by means of the immunohistochemmical detection of phosphorylated STAT5 (element of the major signalling pathway of the prolactin receptor). This work found evidence that in most of the analysed brain regions (the CeM, MePD, LSV, AC/ADP, MPOM, Pa, PIL and LPAG), pSTAT5-immunoreactivity (measure of lactogenic signalling) increased significantly with motherhood. Moreover, godmothers showed increased PRL signalling as compared to virgins in some key brain regions in maternal behaviour regulation, specifically the MPOM and the PIL. This suggests that pup-derived stimuli are exerting a sensitisation to prolactin in these nuclei. This might be at the base of the increase in maternal motivation observed in godmothers. This work discusses the putative mechanisms underlying this process | ca_CA |
dc.format.extent | 33 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Universitat Jaume I | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Màster Universitari en Investigació en Cervell i Conducta | ca_CA |
dc.subject | Máster universitario en Investigación en Cerebro y Conducta | ca_CA |
dc.subject | Master's Degree in Research on the Brain and Behaviour | ca_CA |
dc.subject | Maternal behaviour | ca_CA |
dc.subject | Prolactin | ca_CA |
dc.subject | Neuroendocrinology | ca_CA |
dc.subject | Maternal motivation | ca_CA |
dc.subject | Sociosexual brain | ca_CA |
dc.subject | Maternal sensitisation | ca_CA |
dc.title | Pup-derived stimulation induces increased response to PRL in the female mouse brain: implications for motivated maternal behaviour | ca_CA |
dc.type | info:eu-repo/semantics/masterThesis | ca_CA |
dc.educationLevel | Estudios de Postgrado | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |