Enhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implants
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Otros documentos de la autoría: Ibáñez, Maria; Sanjeeva Murthy, N.; Mao, Yong; Suay, Julio; GURRUCHAGA, MARILO; Goñi, Isabel; Kohn, Joachim
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INVESTIGACIONMetadatos
Título
Enhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implantsAutoría
Fecha de publicación
2018-03Editor
WileyTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33889Versión
info:eu-repo/semantics/draftPalabras clave / Materias
Resumen
A series of sol–gel derived silicon based coatings
were developed to improve the osseointegration of commer-
cial titanium dental implants. The osseointegration starts
with a positive interaction between the implant ... [+]
A series of sol–gel derived silicon based coatings
were developed to improve the osseointegration of commer-
cial titanium dental implants. The osseointegration starts
with a positive interaction between the implant surface and
surrounding tissues, which is facilitated by the adsorption of
plasma proteins onto the biomaterial surface immediately
after implantation. It is likely that the enhancement of protein
adsorption to titanium implants leads to a better implant/tis-
sue integration. In addition, silica based biomaterials have
been shown to promote osteoblast differentiation. To
improve the protein adsorption and the osteogenesis, meth-
yltrimethoxysilane (MTMOS), tetraethoxysilane (TEOS), 3-
glycidoxypropyltrimethoxysilane (GPTMS), and gelatin were
selected to coat titanium surfaces. Compared with non-
coated titanium, the functionalized coatings enhanced the adsorption of adhesive proteins such as fibronectin and colla-
gen. The Si release was successfully modulated by the con-
trol of the chemical composition of the coating, showing a
higher dissolution rate with the gelatin and GPTMS incorpo-
ration. While the roughness of commercial implants seemed
to promote the adhesion of mesenchymal stem cells (MSC),
the osteogenic differentiation was greater on surfaces with
Si-coatings. In this study, an improved osteogenic surface
has been achieved by using the siloxane-gelatin coatings and
such coatings can be used in dental implants to promote
osseointegration. [-]
Proyecto de investigación
Ministerio de Economía y Competitividad, Govern of Spain (MAT2014‐51918‐C2‐2 R ) ; University of the Basque Country (UFI 11/56; IT 611–13)Derechos de acceso
Copyright © 2017 Wiley Periodicals, Inc.
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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