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Synthesis of a New Proteasome Inhibitor Displaying an α-Keto β-Epoxyester Warhead
dc.contributor.author | Bou Iserte, Lledó | |
dc.contributor.other | González Adelantado, Florenci Vicent | |
dc.contributor.other | Universitat Jaume I. Departament de Química Inorgànica i Orgànica | |
dc.date.accessioned | 2018-03-28T07:40:10Z | |
dc.date.available | 2018-03-28T07:40:10Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://hdl.handle.net/10234/173794 | |
dc.description | Treball Final del Màster Universitari en Química Aplicada i Farmacològica. Codi: SIM138. Curs acadèmic 2016/2017 | ca_CA |
dc.description.abstract | In this work, the design and synthesis of a new proteasome inhibitor warhead has been accomplished. Chemical structure of the inhibitor displays three fragments: an α-keto β- epoxyester moiety as a warhead, a dipeptidyl linker and an azido-L-phenylalanine as a “clickable” part with a tag. The desired inhibitor has been prepared through a convergent synthesis of the three fragments. The synthesis of the warhead has two key steps: a Morita-Baylis-Hillman reaction and an epoxidation reaction. | ca_CA |
dc.format.extent | 80 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Universitat Jaume I | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Màster Universitari en Química Aplicada i Farmacològica | ca_CA |
dc.subject | Máster Universitario en Química Aplicada y Farmacológica | ca_CA |
dc.subject | Master's Degree in Applied and Pharmacology Chemistry | ca_CA |
dc.subject | anticancer agents | ca_CA |
dc.subject | inhibitors | ca_CA |
dc.subject | proteasome | ca_CA |
dc.subject | epoxides | ca_CA |
dc.subject | Morita-Baylis-Hillman reaction | ca_CA |
dc.title | Synthesis of a New Proteasome Inhibitor Displaying an α-Keto β-Epoxyester Warhead | ca_CA |
dc.type | info:eu-repo/semantics/masterThesis | ca_CA |
dc.educationLevel | Estudios de Postgrado | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |