Synthesis of a New Proteasome Inhibitor Displaying an α-Keto β-Epoxyester Warhead
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Título
Synthesis of a New Proteasome Inhibitor Displaying an α-Keto β-Epoxyester WarheadAutoría
Tutor/Supervisor; Universidad.Departamento
González Adelantado, Florenci Vicent; Universitat Jaume I. Departament de Química Inorgànica i OrgànicaFecha de publicación
2017Editor
Universitat Jaume IResumen
In this work, the design and synthesis of a new proteasome inhibitor warhead has been
accomplished. Chemical structure of the inhibitor displays three fragments: an α-keto β-
epoxyester moiety as a warhead, a ... [+]
In this work, the design and synthesis of a new proteasome inhibitor warhead has been
accomplished. Chemical structure of the inhibitor displays three fragments: an α-keto β-
epoxyester moiety as a warhead, a dipeptidyl linker and an azido-L-phenylalanine as a
“clickable” part with a tag. The desired inhibitor has been prepared through a convergent
synthesis of the three fragments. The synthesis of the warhead has two key steps: a
Morita-Baylis-Hillman reaction and an epoxidation reaction. [-]
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Descripción
Treball Final del Màster Universitari en Química Aplicada i Farmacològica. Codi: SIM138. Curs acadèmic 2016/2017
Tipo de documento
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