Study of cationic polymers as supports for photosensitizers with application in photodynamic therapy
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Title
Study of cationic polymers as supports for photosensitizers with application in photodynamic therapyAuthor (s)
Tutor/Supervisor; University.Department
Galindo Honrubia, Francisco; Universitat Jaume I. Departament de Química Inorgànica i OrgànicaDate
2016Publisher
Universitat Jaume IAbstract
Resistance to antibiotics by microorganism has increased in the last
decades. Due to the increased resistance, it is very important to look for
alternative ways to fight bacterial infections.
Almost all microorganisms ... [+]
Resistance to antibiotics by microorganism has increased in the last
decades. Due to the increased resistance, it is very important to look for
alternative ways to fight bacterial infections.
Almost all microorganisms can form biofilm on a wide range of surfaces i.e.
biological and inert ones. Biofilm presence causes a great problem for public
health due to its resistant nature to antibiotics and disease associated with
indwelling medical devices (for instance, catheters). Biofilm forming capability has
been reported in large number of bacterial species such as P. aeruginosa, S.
epidermidis, E. coli spp, S. aureus, E. cloacae and K. pneumonia.[1]
It has been estimated that healthcare associated infections cause 37,000
deaths in Europe every year, with an economic burden of €13 - 24 billion.[2] In the
United States, the estimated death toll is about 99,000 every year, with an
economic cost of $33 billion.[3] Although the general public is becoming slowly
aware of this global threat, public institutions have been warning since long time
ago about the imminent crisis on this regard. The problem could reach in the
future unprecedented proportions since microbial resistance has been recently
described both as a ‘One Health Issue’ and as a ‘One World Issue’.[4]
Therefore, the search for new techniques to reduce bacterial infections is of
vital importance. Increasing attention is currently devoted to the development of surfaces disfavouring the adhesion of bacteria and hence impeding the formation
of biofilms. One of the strategies consists in the use of cationic groups able to
disrupt the membrane of the microorganism (alkylamonium, phosphonium,
sulfonium, etc). Anhother strategy to fight bacterial infections is the antimicrobial
photodynamic therapy (aPDT). [-]
Subject
Description
Treball Final del Màster Universitari en Química Aplicada i Farmacològica. Codi: SIM138. Curs acadèmic 2016/2017
Type
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