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Polyphenol intake from a Mediterranean dietdecreases inflammatory biomarkers related toatherosclerosis: a substudy of the PREDIMED trial
dc.contributor.author | Medina Remón, A. | |
dc.contributor.author | Casas, Rosa | |
dc.contributor.author | Tresserra-Rimbau, Anna | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Martínez González, Miguel Ángel | |
dc.contributor.author | Fitó, Montserrat | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Salas-Salvadó, Jordi | |
dc.contributor.author | Lamuela Raventós, Rosa María | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | PREDIMED Investigators | |
dc.date.accessioned | 2017-06-07T07:30:33Z | |
dc.date.available | 2017-06-07T07:30:33Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | MEDINA‐REMÓN, Alexander, et al. Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial. British journal of clinical pharmacology, 2017, vol. 83, no 1, p. 114-128. | ca_CA |
dc.identifier.issn | 0306-5251 | |
dc.identifier.issn | 1365-2125 | |
dc.identifier.uri | http://hdl.handle.net/10234/167896 | |
dc.description.abstract | High dietary polyphenol intake is associated with reduced all-cause mortality and a lower incidence of cardiovascular events. However, the mechanisms involved are not fully understood. The aim of the present substudy of the PREvención con DIetaMEDiterránea (Prevention with Mediterranean diet; PREDIMED) trial was to analyse the relationship between polyphenol intake measured by total urinary polyphenol excretion (TPE), and circulating inflammatory biomarkers and cardiovascular risk factors in elderly individuals. A substudy of 1139 high-risk participants was carried out within the PREDIMED trial. The subjects were randomly assigned to a low-fat control diet or to two Mediterranean diets, supplemented with either extra-virgin olive oil or nuts. Dietary intake, anthropometric data, clinical and laboratory assessments, including inflammatory biomarkers, and urinary TPE were measured at baseline and after the one-year intervention. Participants in the highest tertile of changes in urinary TPE (T3) showed significantly lower plasma levels of inflammatory biomarkers [vascular cell adhesion molecule 1 (VCAM-1) (–9.47 ng ml–1), intercellular adhesion molecule 1 (–14.71 ng ml–1), interleukin 6 (–1.21 pg ml–1), tumour necrosis factor alpha (–7.05 pg ml–1) and monocyte chemotactic protein 1 (–3.36 pg ml–1)] than those inthe lowest tertile (T1, P < 0.02; all). A significant inverse correlation existed between urinary TPE and the plasma concentration of\VCAM-1 (r = –0.301; P < 0.001). In addition, systolic and diastolic blood pressure (BP) decreased and plasma high-density lipoprotein cholesterol increased in parallel with increasing urinary TPE (T3 vs. T1) (P < 0.005 and P = 0.004, respectively). Increases in polyphenol intake measured as urinary TPE are associated with decreased inflammatory biomarkers, suggesting a dose-dependent anti-inflammatory effect of polyphenols. In addition, high polyphenol intake improves cardiovascular risk factors– mainly BP and the lipid profile. | ca_CA |
dc.description.sponsorShip | We would like to thank all the volunteers involved in the PREDIMED study for their valuable cooperation. This study was supported in part by CICYT (AGL2010-22319-C03) from the Spanish Min stry of Science and Innovation (MICINN); and the Instituto de Salud Carlos III, ISCIII (CI BERobn-CB06/03,PI1002658, and PI1001407). The CIBEROBN is an initiative of the ISCII I, Spain. AT-R received support from ISCIII (FI10/00265).A. M.-R. thanks the ‘Juan de la Cierva’ postdoctoral program(JCI-2012-13463) from MEC (Ministerio de Economía yCompetitividad). The MICINN, MEC and ISCIII had no role in the design, analysis or writing of this article | ca_CA |
dc.format.extent | 15 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.relation.isFormatOf | Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial. British journal of clinical pharmacology, 2017, vol. 83, no 1, p. 114-128. | ca_CA |
dc.relation.isPartOf | British journal of clinical pharmacology, 2017, vol. 83, no 1 | ca_CA |
dc.rights | Copyright © John Wiley & Sons, Inc. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | blood pressure | ca_CA |
dc.subject | Folin–Ciocalteu | ca_CA |
dc.subject | hypertension | ca_CA |
dc.subject | inflammatory biomarkers | ca_CA |
dc.subject | Mediterranean diet | ca_CA |
dc.subject | urinary polyphenol biomarker | ca_CA |
dc.title | Polyphenol intake from a Mediterranean dietdecreases inflammatory biomarkers related toatherosclerosis: a substudy of the PREDIMED trial | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1111/bcp.12986 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://onlinelibrary.wiley.com/doi/10.1111/bcp.12986/full | ca_CA |
dc.type.version | info:eu-repo/semantics/acceptedVersion |
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