Efavirenz and the CNS: what we already know and questions that need to be answered
Impacto
Scholar |
Otros documentos de la autoría: Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Galindo, Maria J.; Álvarez, Ángeles; Esplugues, Juan V.
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONEste recurso está restringido
http:\\dx.doi.org/10.1093/jac/dkv183 |
Metadatos
Título
Efavirenz and the CNS: what we already know and questions that need to be answeredAutoría
Fecha de publicación
2015-07Editor
Oxford University PressCita bibliográfica
APOSTOLOVA, Nadezda, et al. Efavirenz and the CNS: what we already know and questions that need to be answered. Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no 10, p. 2693-2708.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://jac.oxfordjournals.org/content/70/10/2693.shortVersión
info:eu-repo/semantics/publishedVersionResumen
The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs in the multidrug
regimens used to treat HIV infection, in accordance with its well-demonstrated antiretroviral efficacy and ... [+]
The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs in the multidrug
regimens used to treat HIV infection, in accordance with its well-demonstrated antiretroviral efficacy and favourable
pharmacokinetics. However, growing concern about its adverse effects has sometimes led to efavirenz being
replaced by other drugs in the initial treatment selection or to switching of therapy to efavirenz-free regimens in
experienced patients. Neurological and neuropsychiatric reactions are the manifestations most frequently experienced
by efavirenz-treated patients and range from transitory effects, such as nightmares, dizziness, insomnia,
nervousness and lack of concentration, to more severe symptoms including depression, suicidal ideation or even
psychosis. In addition, efavirenz has recently been associated with mild/moderate neurocognitive impairment,
which is of specific relevance given that half of the patients receiving ART eventually suffer some form of HIVassociated
neurocognitive disorder. The mechanisms responsible for efavirenz-induced neurotoxicity are unclear,
although growing evidence points to disturbances in brain mitochondrial function and bioenergetics. This review
offers a comprehensive overview of the current evidence on the interaction that efavirenz displays with the CNS,
including the penetration and concentration of the drug in the brain. We discuss the prevalence, types and
specificities of its side effects and recently uncovered cellular mechanisms that may be involved in their
development. [-]
Publicado en
Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no 10Derechos de acceso
© The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
Aparece en las colecciones
- MED_Articles [671]