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Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression
dc.contributor.author | Martí-Centelles, Rosa | |
dc.contributor.author | Murga, Juan | |
dc.contributor.author | Falomir, Eva | |
dc.contributor.author | Carda, Miguel | |
dc.contributor.author | Marco, J. Alberto | |
dc.date.accessioned | 2016-06-06T07:14:13Z | |
dc.date.available | 2016-06-06T07:14:13Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | MARTÍ-CENTELLES, Rosa, et al. Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression. MedChemComm, 2015, vol. 6, no 10, p. 1809-1815. | ca_CA |
dc.identifier.issn | 2040-2503 | |
dc.identifier.issn | 2040-2511 | |
dc.identifier.uri | http://hdl.handle.net/10234/160332 | |
dc.description.abstract | A group of 21 nitrogen-containing heterocyclic stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity as well as their ability to inhibit the production of the vascular endothelial growth factor (VEGF) and the activation of telomerase. The ability of these compounds to inhibit proliferation of two tumoral cell lines (HT-29 and MCF-7) and one non-tumoral cell line (HEK-293) was first determined. Subsequently, we determined the capacity of the compounds to inhibit the secretion of VEGF in the aforementioned cell lines and downregulate the expression of the VEGF, hTERT and c-Myc genes, of which the latter two are involved in controlling the activation of telomerase. | ca_CA |
dc.description.sponsorShip | Financial support has been granted by the Spanish Government (MINECO, Ministerio de Economía y Competitividad, project CTQ2011-27560), the Consellería d'Empresa, Universitat i Ciencia de la Generalitat Valenciana (projects PROMETEO/2013/027 and ACOMP/2014/272) and the Universitat Jaume I (PI-1B-2011-37). R. M.-C. thanks the Universitat Jaume I for a pre-doctoral fellowship. | ca_CA |
dc.format.extent | 7 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | The Royal Society of Chemistry | ca_CA |
dc.relation.isPartOf | MedChemComm, 2015, vol. 6, no 10 | ca_CA |
dc.rights | © Royal Society of Chemistry | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | stilbenes | ca_CA |
dc.subject | VEGF | ca_CA |
dc.subject | hTERT | ca_CA |
dc.subject | c-Myc | ca_CA |
dc.title | Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1039/c5md00197h | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://pubs.rsc.org/en/content/articlehtml/2015/md/c5md00197h | ca_CA |
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