Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression
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Other documents of the author: Martí-Centelles, Rosa; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto
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comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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http://dx.doi.org/10.1039/c5md00197h |
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Title
Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expressionDate
2015Publisher
The Royal Society of ChemistryISSN
2040-2503; 2040-2511Bibliographic citation
MARTÍ-CENTELLES, Rosa, et al. Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression. MedChemComm, 2015, vol. 6, no 10, p. 1809-1815.Type
info:eu-repo/semantics/articlePublisher version
http://pubs.rsc.org/en/content/articlehtml/2015/md/c5md00197hAbstract
A group of 21 nitrogen-containing heterocyclic stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity as well as their ability to inhibit the production of the ... [+]
A group of 21 nitrogen-containing heterocyclic stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity as well as their ability to inhibit the production of the vascular endothelial growth factor (VEGF) and the activation of telomerase. The ability of these compounds to inhibit proliferation of two tumoral cell lines (HT-29 and MCF-7) and one non-tumoral cell line (HEK-293) was first determined. Subsequently, we determined the capacity of the compounds to inhibit the secretion of VEGF in the aforementioned cell lines and downregulate the expression of the VEGF, hTERT and c-Myc genes, of which the latter two are involved in controlling the activation of telomerase. [-]
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MedChemComm, 2015, vol. 6, no 10Rights
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