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Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cells
dc.contributor.author | Wadhavane, Prashant Dinkar | |
dc.contributor.author | Izquierdo Arcusa, María Ángeles | |
dc.contributor.author | Lutters, Dennis | |
dc.contributor.author | Burguete, M. Isabel | |
dc.contributor.author | Marín, María J. | |
dc.contributor.author | Russell, David A. | |
dc.contributor.author | Galindo, Francisco | |
dc.contributor.author | Luis, Santiago V. | |
dc.date.accessioned | 2015-07-23T07:00:08Z | |
dc.date.available | 2015-07-23T07:00:08Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | WADHAVANE, Prashant D., et al. Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cells. Organic & biomolecular chemistry, 2014, vol. 12, no 5, p. 823-831. | ca_CA |
dc.identifier.issn | 1477-0520 | |
dc.identifier.issn | 1477-0539 | |
dc.identifier.uri | http://hdl.handle.net/10234/128665 | |
dc.description.abstract | A new family of acidity sensitive fluorescent macrocycles has been synthesized and fully characterized. Their photophysical properties including emission quantum yield and fluorescence lifetime have been determined. The acid–base properties of the new molecules can be tuned by the incorporation of pendant functional groups. The nature of such functional groups (carboxylic acid or ester) influences dramatically the pKa of the probes, two compounds of which exhibit low values. Preliminary intracellular studies using confocal microscopy together with emission spectra of the probes from the cellular environment have shown that the synthesized fluorescent macrocycles mark the acidic organelles of RAW 264.7 macrophage cells. | ca_CA |
dc.description.sponsorShip | Financial support from the Spanish MINECO (CTQ2012-38543-C03-01) and UJI (project P1·1B-2012-41) are acknowledged. P.D.W. thanks the financial support from GV (Grisolia Fellowship). M.J.M. acknowledges the School of Chemistry (University of East Anglia, Norwich, UK) for a studentship. The authors are grateful to Dr Jelena Gavrilovic (School of Biological Sciences, University of East Anglia, Norwich, UK) for the kind gift of the RAW 264.7 mouse macrophage cells used in this work. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Royal Society of Chemistry | ca_CA |
dc.relation.isPartOf | Organic & biomolecular chemistry, 2014, vol. 12, no 5 | ca_CA |
dc.rights | © 2014 The Royal Society of Chemistry. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | acid-base property | ca_CA |
dc.subject | cellular environment | ca_CA |
dc.subject | emission quantum yield | ca_CA |
dc.subject | emission spectrums | ca_CA |
dc.subject | fluorescence lifetimes | ca_CA |
dc.subject | pendant functional group | ca_CA |
dc.subject | photophysical properties | ca_CA |
dc.subject | raw 264.7macrophages | ca_CA |
dc.title | Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cells | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1039/C3OB41773E | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/C3OB41773E#!divAbstract | ca_CA |
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