Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cells
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http://dx.doi.org/10.1039/C3OB41773E |
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Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cellsAutoria
Data de publicació
2014Editor
Royal Society of ChemistryISSN
1477-0520; 1477-0539Cita bibliogràfica
WADHAVANE, Prashant D., et al. Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cells. Organic & biomolecular chemistry, 2014, vol. 12, no 5, p. 823-831.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/C3OB41773E#!divAbstractParaules clau / Matèries
Resum
A new family of acidity sensitive fluorescent macrocycles has been synthesized and fully characterized. Their photophysical properties including emission quantum yield and fluorescence lifetime have been determined. ... [+]
A new family of acidity sensitive fluorescent macrocycles has been synthesized and fully characterized. Their photophysical properties including emission quantum yield and fluorescence lifetime have been determined. The acid–base properties of the new molecules can be tuned by the incorporation of pendant functional groups. The nature of such functional groups (carboxylic acid or ester) influences dramatically the pKa of the probes, two compounds of which exhibit low values. Preliminary intracellular studies using confocal microscopy together with emission spectra of the probes from the cellular environment have shown that the synthesized fluorescent macrocycles mark the acidic organelles of RAW 264.7 macrophage cells. [-]
Publicat a
Organic & biomolecular chemistry, 2014, vol. 12, no 5Drets d'accés
© 2014 The Royal Society of Chemistry.
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