Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activity
Visualitza/
Impacte
Scholar |
Altres documents de l'autoria: Torijano Gutiérrez, Sandra Adela; Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
comunitat-uji-handle4:
INVESTIGACIONMetadades
Títol
Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic ActivityAutoria
Data de publicació
2014Editor
Wiley Online LibraryISSN
1434-193XTipus de document
info:eu-repo/semantics/articleParaules clau / Matèries
Resum
We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these ... [+]
We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these compounds have been measured and the relationship between the structure and cytotoxicity is discussed. Some of the tested compounds showed cytotoxicity values of the same order of magnitude as those of the parental molecules, combretastatin A-4 and pironetin, and were less toxic than the latter for normal cells. [-]
Publicat a
European Journal of Organic Chemistry, 2014(11)Drets d'accés
This is the pre-peer reviewed version of the following article: Torijano‐Gutiérrez, S., Vilanova, C., Díaz‐Oltra, S., Murga, J., Falomir, E., Carda, M., & Marco, J. A. (2014). Design and Synthesis of Pironetin Analogue/Combretastatin A‐4 Hybrids and Evaluation of Their Cytotoxic Activity. European Journal of Organic Chemistry, 2014(11), 2284-2296.
which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201301725/full]
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
Apareix a les col.leccions
- QUIO_Articles [705]