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dc.contributor.authorTorijano Gutiérrez, Sandra Adela
dc.contributor.authorVilanova Gallén, Concepción
dc.contributor.authorDíaz Oltra, Santiago
dc.contributor.authorMurga Clausell, Juan
dc.contributor.authorFalomir Ventura, Eva
dc.contributor.authorCarda Usó, Miguel
dc.contributor.authorMarco, J. Alberto
dc.date.accessioned2015-07-09T18:15:15Z
dc.date.available2015-07-09T18:15:15Z
dc.date.issued2014
dc.identifier.issn1434-193X
dc.identifier.urihttp://hdl.handle.net/10234/127145
dc.description.abstractWe describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these compounds have been measured and the relationship between the structure and cytotoxicity is discussed. Some of the tested compounds showed cytotoxicity values of the same order of magnitude as those of the parental molecules, combretastatin A-4 and pironetin, and were less toxic than the latter for normal cells.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherWiley Online Libraryca_CA
dc.relation.isPartOfEuropean Journal of Organic Chemistry, 2014(11)ca_CA
dc.rightsThis is the pre-peer reviewed version of the following article: Torijano‐Gutiérrez, S., Vilanova, C., Díaz‐Oltra, S., Murga, J., Falomir, E., Carda, M., & Marco, J. A. (2014). Design and Synthesis of Pironetin Analogue/Combretastatin A‐4 Hybrids and Evaluation of Their Cytotoxic Activity. European Journal of Organic Chemistry, 2014(11), 2284-2296. which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201301725/full]ca_CA
dc.subjectmedicinal chemistryca_CA
dc.subjectdrug designca_CA
dc.subjectcytotoxicityca_CA
dc.subjectcytotoxicityca_CA
dc.subjectanticancer agentsca_CA
dc.subjectstructure–activity relationshipsca_CA
dc.titleDesign and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activityca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1002/ejoc.201301725
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA


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