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Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activity
dc.contributor.author | Torijano Gutiérrez, Sandra Adela | |
dc.contributor.author | Vilanova Gallén, Concepción | |
dc.contributor.author | Diaz-Oltra, Santiago | |
dc.contributor.author | Murga, Juan | |
dc.contributor.author | Falomir, Eva | |
dc.contributor.author | Carda, Miguel | |
dc.contributor.author | Marco, J. Alberto | |
dc.date.accessioned | 2015-07-09T18:15:15Z | |
dc.date.available | 2015-07-09T18:15:15Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1434-193X | |
dc.identifier.uri | http://hdl.handle.net/10234/127145 | |
dc.description.abstract | We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these compounds have been measured and the relationship between the structure and cytotoxicity is discussed. Some of the tested compounds showed cytotoxicity values of the same order of magnitude as those of the parental molecules, combretastatin A-4 and pironetin, and were less toxic than the latter for normal cells. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Wiley Online Library | ca_CA |
dc.relation.isPartOf | European Journal of Organic Chemistry, 2014(11) | ca_CA |
dc.rights | This is the pre-peer reviewed version of the following article: Torijano‐Gutiérrez, S., Vilanova, C., Díaz‐Oltra, S., Murga, J., Falomir, E., Carda, M., & Marco, J. A. (2014). Design and Synthesis of Pironetin Analogue/Combretastatin A‐4 Hybrids and Evaluation of Their Cytotoxic Activity. European Journal of Organic Chemistry, 2014(11), 2284-2296. which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201301725/full] | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | medicinal chemistry | ca_CA |
dc.subject | drug design | ca_CA |
dc.subject | cytotoxicity | ca_CA |
dc.subject | cytotoxicity | ca_CA |
dc.subject | anticancer agents | ca_CA |
dc.subject | structure–activity relationships | ca_CA |
dc.title | Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activity | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1002/ejoc.201301725 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
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