Listar por autoría "0d5fcc18-8638-449a-b96b-b1a66b29f014"
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Molecular Characterization of the Viroporin Function of Foot-and-Mouth Disease Virus Nonstructural Protein 2B
Gladue, Douglas; Largo, Eneko; de la Arada, Igor; Aguilella, Vicente; Alcaraz, Antonio; Arrondo, Jose Luis; Holinka, L.G.; Brocchi, Emiliana; Ramirez-Medina, Elizabeth; Vuono, Elizabeth; Berggren, Keith; Carrillo, C.; Nieva, Jose L; Borca, Manuel V. American Society for Microbiology (2018-12)Nonstructural protein 2B of foot-and-mouth disease (FMD) virus (FMDV) is comprised of a small, hydrophobic, 154-amino-acid protein. Structure-function analyses demonstrated that FMDV 2B is an ion channel-forming protein. ... -
Mutation-induced changes of transmembrane pore size revealed by combined ion-channel conductance and single vesicle permeabilization analyses
Largo, Eneko; Gladue, Douglas; Torralba, Johana; Aguilella, Vicente; Alcaraz, Antonio; Borca, Manuel V.; Nieva, José L. Elsevier (2018-05)Permeabilization of the Endoplasmic Reticulum (ER) is instrumental in the progression of host-cell infection by many viral pathogens. We have described that permeabilization of ER model membranes by the pore-forming domain ...