Listar por autoría "20cbfd6f-e235-46af-a4ed-69f9a8df41c7"
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A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
Corella, Dolores; Coltell, Oscar; Portolés, Olga; Sotos-Prieto, Mercedes; Fernández-Carrión, Rebeca; Ramírez-Sabio, Judith B.; Zanón-Moreno, Vicente; Mattei, Josiemer; Sorlí, José V; Ordovás Muñoz, José M. MDPI (2019)Precision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of ... -
Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial
CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Estruch, Ramon; Asensio, Eva Maria; Coltell, Oscar; González, José I.; Martínez González, Miguel Ángel; Ros, Emilio; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Flores, Gemma; Pintó, Xavier; Sáiz, Carmen; Ordovás Muñoz, José M.; Corella, Dolores American Heart Association (2014-02)Background: A variant (rs3812316, C771G, Gln241His) in the MLXIPL (Max-like protein X interacting protein-like) gene encoding the carbohydrate response element binding protein has been associated with lower triglycerides. ... -
Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population
Asensio, Eva Maria; Ortega-Azorín, Carolina; Barragán-Arnal, Rocío; Alvarez-Sala, Andrea; Sorlí, José V; Pascual, Eva C.; Fernández-Carrión, Rebeca; Villamil, Laura V.; Corella, Dolores; Coltell, Oscar MDPI (2022)Background and Objectives: The gut microbiota has been increasingly recognized as a relevant factor associated with metabolic diseases. However, directly measuring the microbiota composition is a limiting factor for ... -
Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction
Corella, Dolores; Tai, E-Shyong; Sorlí, José V; Chew, Suok Kai; Coltell, Oscar; Sotos Prieto, Mercedes; García Ríos, Antonio; Estruch, Ramon; Ordovás Muñoz, José M. Nature Publishing Group (2011-05)Objective: The APOA2 gene has been associated with obesity and insulin resistance (IR) in animal and human studies with controversial results. We have reported an APOA2–saturated fat interaction determining body mass index ... -
Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population
Corella, Dolores; Arregui, María; Coltell, Oscar; Portolés, Olga; Guillem Sáiz, Patricia; Carrasco, Paula; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Ordovás Muñoz, José M. Nature Publishing Group (2011-08)The -13910C>T polymorphism (rs4988235) upstream from the lactase (LCT) gene, strongly associated with lactase persistence (LP) in Europeans, is emerging as a new candidate for obesity. We aimed to analyze the association ... -
Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulate by diet, being higher when adherence to the Mediterranean diet pattern is low
Coltell, Oscar; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Sáez Tormo, Guillermo; Pintó, Xavier; Muñoz, Miguel Ángel; Ordovás Muñoz, José M.; Estruch, Ramon; Corella, Dolores; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Asensio, Eva Maria; Covas Planells, María Isabel; Ros, Emilio BioMed Central (2012-11)Background: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is ... -
Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization
Smith, C.E.; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Dashti, Hassan S.; Lai, Chao-Qiang; Miró, Leticia; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Ros, Emilio; Aslibekyan, Stella; Hidalgo, Bertha; Neuhouser, Marian L.; Di, Chongzhi; Tucker, Katherine; Arnett, Donna K.; Ordovás Muñoz, José M.; Corella, Dolores Nature Publishing Group (2016)Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through ... -
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects
Barragán-Arnal, Rocío; Coltell, Oscar; Portolés, Olga; Asensio, Eva Maria; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Sáiz, Carmen; Fernández-Carrión, Rebeca; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2018)There is growing interest in relating taste perception to diet and healthy aging. However, there is still limited information on the influence of age, sex and genetics on taste acuity as well as on the relationship between ... -
Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects
CAROLINA, ORTEGA-AZORÍN; Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; González, José I.; Portolés, Olga; Saiz, Carmen; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pérez-Fidalgo, J. Alejandro; Ordovas, Jose; Corella, Dolores MDPI (2019)Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance. However, the genes and gene variants that influence its plasma levels are still not well known. Results of studies investigating ... -
Circulating adiponectin and Its association with metabolic traits and Type 2 Diabetes: gene-diet interactions focusing on selected gene variants and at the genome-wide level in high-cardiovascular risk mediterranean subjects
Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Portolés, Olga; Asensio, Eva Maria; Saiz, Carmen; Barragán-Arnal, Rocío; Estruch, Ramon; Corella, Dolores MDPI (2021-02-07)Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence ... -
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial
Corella, Dolores; Asensio, Eva Maria; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Castañer, Olga; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; CAROLINA, ORTEGA-AZORÍN; Fiol Ramis, Miquel; Díez Espino, Javier; Díaz López, Andrés; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. BioMed Central (2016-01)Background Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by ... -
Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial
Martínez González, Miguel Ángel; Buil-Cosiales, Pilar; Corella, Dolores; Bulló, Mònica; Fitó, Montserrat; Vioque, Jesus; Romaguera, Dora; Martínez, J. Alfredo; Wärnberg, Julia; López Miranda, José; Estruch, Ramon; Bueno Cavanillas, Aurora; Arós, Fernando; Tur, Josep; Tinahones Madueño, Francisco José; Serra-Majem, Lluis; Martín, Vicente; Lapetra, José; Vázquez, Clotilde; Pintó, Xavier; Vidal, Josep; Daimiel-Ruiz, Lidia Ángeles; Delgado Rodríguez, Miguel; Matía, Pilar; Ros, Emilio; Fernández Aranda, Fernando; Botella, Cristina; Puy Portillo-Baquedano, María; Lamuela Raventós, Rosa María; Marcos, Ascensión; Sáez, Guillermo; Gómez-Gracia, Enrique; Ruiz-Canela, Miguel; Toledo, Estefanía; Alvarez-Alvarez, Ismael; Díez Espino, Javier; Sorlí, José V; Basora, Josep; Castañer, Olga; Schröder, Helmut; Navarrete-Muñoz, Eva María; Zulet, M. Angeles; García-Rios, Antonio; Salas-Salvadó, Jordi Oxford University Press (2019-04)The PREDIMED (in Spanish: PREvención con DIeta MEDiterránea) primary prevention trial1–3 reported in 2013 that long-term adherence to an energy-unrestricted Mediterranean diet (MedDiet), supplemented with either extra-virgin ... -
Crosstalk between smoking and the genome in older subjects with metabolic syndrome through genomics, epigenomics and transcriptomics
Coltell, Oscar; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Barragán-Arnal, Rocío; Sáiz, Carmen; Portolés, Olga; Sorlí, José V; Corella, Dolores European Molecular Biology Organization (EMBO) (2019-09-11)Tobacco smoking (Figure 1) is a major cause of cardiovascular diseases (CVD), and appears to have a multiplicative interaction with the other major CVD risk factors (lipids, hypertension, diabetes and others present in the ... -
Dietary alpha-Linolenic Acid, Marine omega-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
Sala-Vila, Aleix; Guash-Ferré, Marta; Hu, Frank B.; Sánchez-Tainta, Ana; Bulló, Mònica; Serra-Mir, Mercè; López-Sabater, Maria Carmen; Sorlí, José V; Arós, Fernando; Fiol Ramis, Miquel; Muñoz, Miguel Ángel; Serra-Majem, Lluis; Martínez, J. Alfredo; Corella, Dolores; Fitó, Montserrat; Salas-Salvadó, Jordi; Martínez González, Miguel Ángel; Estruch, Ramon; Ros, Emilio; Coltell, Oscar; PREDIMED Investigators American Heart Association (2016-01)Background Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain ... -
Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population
Corella, Dolores; Carrasco, Paula; Sorlí, José V; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Guillen, Montserrat; González, José I.; Sáiz, Carmen; Estruch, Ramon; Ordovás Muñoz, José M. Elsevier (2012)Objective To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean ... -
Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet
Corella, Dolores; Ramírez-Sabio, Judith B.; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Estruch, Ramon; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Sorlí, José V; Castañer, Olga; Arós, Fernando; García-Corte, Franscisco J.; Serra-Majem, Lluis; Gómez-Gracia, Enrique; Fiol Ramis, Miquel; Pintó, Xavier; Sáez, Guillermo T.; Toledo, Estefanía; Basora, Josep; Fitó, Montserrat; Cofán, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. Elsevier (2018-04)Background Oxidatively induced DNA damage, an important factor in cancer etiology, is repaired by oxyguanine glycosylase 1 (OGG1). The lower repair capacity genotype (homozygote Cys326Cys) in the OGG1-rs1052133 (Ser326Cys) ... -
Genome-wide association analyses of weight loss in a randomized controlled trial of lifestyle intervention, and combined transcriptome-wide associations in a Mediterranean population
Corella, Dolores; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Fernández-Carrión, Rebeca; Barragán-Arnal, Rocío; González, José I.; Coltell, Oscar European Molecular Biology Organization (EMBO) (2019-09-11)Although large-scale genome-wide association studies (GWAS) for obesity traits have identified more than 400 associated loci from observational studies (Figure 1), we highlight the fact that currently the number of GWAS ... -
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Barragán-Arnal, Rocío; Fernández-Carrión, Rebeca; Portolés, Olga; CAROLINA, ORTEGA-AZORÍN; Martínez-LaCruz, Raúl; González, José I.; Zanón-Moreno, Vicente; Gimenez Alba, Ignacio Manuel; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2019)Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is ... -
Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome
Coltell, Oscar; Sorlí, José V; Asensio, Eva Maria; Barragán-Arnal, Rocío; González, José I.; Gimenez Alba, Ignacio Manuel; Zanón-Moreno, Vicente; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pascual, Eva C.; CAROLINA, ORTEGA-AZORÍN; Ordovas, Jose; Corella, Dolores MDPI (2020)Many early studies presented beneficial effects of polyunsaturated fatty acids (PUFA) on cardiovascular risk factors and disease. However, results from recent meta-analyses indicate that this effect would be very low or ... -
Impact of the -1438G>A polymorphism in the serotonin 2A receptor gene on anthropometric profile and obesity risk: A case-control study in a Spanish Mediterranean population
Sorlí, José V; Francés, F.; González, José I.; Guillen, Montserrat; Portolés, Olga; Sabater, Antonio; Coltell, Oscar; Corella, Dolores (2008)Research into the genetic factors that regulate food intake is arousing great interest. The polymorphism -1438G>A in the serotonin 2A receptor or 5-hydroxytriptamine (5-HT) type 2A receptor (5-HTR2A) gene has been ...