Synthesis of compounds with potential biomedical activity: SARS-CoV-2 main protease inhibitors and ABA analogs
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/29747
comunitat-uji-handle3:10234/162741
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TESISMetadata
Title
Synthesis of compounds with potential biomedical activity: SARS-CoV-2 main protease inhibitors and ABA analogsAuthor (s)
Director
González, FlorenciDoctoral Studies
Programa de Doctorat en CiènciesResponsible entity
Universitat Jaume I. Escola de DoctoratDate of defense
2024-04-17Publisher
Universitat Jaume ISubject
Keywords
Pages
313 p.Abstract
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has increased the development of new antiviral drugs to stop its spread. This work focused on synthesizing specific inhibitors of the Mpro protease, crucial for ... [+]
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has increased the development of new antiviral drugs to stop its spread. This work focused on synthesizing specific inhibitors of the Mpro protease, crucial for the virus replication. Compounds with a nitroalkene-type "warhead" were synthesized, showing promising inhibitory activity against this enzyme. Additionally, inhibitors with a keto vinyl sulfone-type "warhead" were synthesized, showing variable inhibition trends against Mpro, CatL, and rhodesain. Furthermore, an ABA antagonist was synthesized, delaying shoot development and fruit generation, offering potential improvements in crop yield. Lastly, fluorescent derivatives of ABA were synthesized, shedding light on its cellular mechanisms. These findings contribute to the development of antiviral drugs and highlight the diverse roles of ABA beyond plants, potentially benefiting human health. [-]
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L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
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