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Synthesis of compounds with potential biomedical activity: SARS-CoV-2 main protease inhibitors and ABA analogs
dc.contributor | Universitat Jaume I. Escola de Doctorat | |
dc.contributor.author | De la Hoz Rodríguez, Sergio | |
dc.date.accessioned | 2024-04-23T10:47:16Z | |
dc.date.accessioned | 2024-07-15T12:01:06Z | |
dc.date.available | 2024-07-15T12:01:06Z | |
dc.date.issued | 2024-04-17 | |
dc.identifier.uri | http://hdl.handle.net/10803/690696 | |
dc.description.abstract | The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has increased the development of new antiviral drugs to stop its spread. This work focused on synthesizing specific inhibitors of the Mpro protease, crucial for the virus replication. Compounds with a nitroalkene-type "warhead" were synthesized, showing promising inhibitory activity against this enzyme. Additionally, inhibitors with a keto vinyl sulfone-type "warhead" were synthesized, showing variable inhibition trends against Mpro, CatL, and rhodesain. Furthermore, an ABA antagonist was synthesized, delaying shoot development and fruit generation, offering potential improvements in crop yield. Lastly, fluorescent derivatives of ABA were synthesized, shedding light on its cellular mechanisms. These findings contribute to the development of antiviral drugs and highlight the diverse roles of ABA beyond plants, potentially benefiting human health. | ca |
dc.format.extent | 313 p. | ca |
dc.language.iso | eng | ca |
dc.publisher | Universitat Jaume I | |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.source | TDX (Tesis Doctorals en Xarxa) | |
dc.subject | SARS-CoV-2 | ca |
dc.subject | Main protease | ca |
dc.subject | Warhead | ca |
dc.subject | Inhibitor | ca |
dc.subject | Abscisic acid | ca |
dc.subject.other | Ciències | ca |
dc.title | Synthesis of compounds with potential biomedical activity: SARS-CoV-2 main protease inhibitors and ABA analogs | ca |
dc.type | info:eu-repo/semantics/doctoralThesis | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | http://dx.doi.org/10.6035/14104.2024.782373 | ca |
dc.subject.udc | 54 | ca |
dc.subject.udc | 615 | ca |
dc.contributor.director | González, Florenci | |
dc.rights.license | L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/ | ca |
dc.rights.accessLevel | info:eu-repo/semantics/embargoedAccess | |
dc.embargo.terms | 12 mesos | ca |
dc.date.embargoEnd | 2025-04-17T02:00:00Z | |
dc.contributor.tutor | González, Florenci | |
dc.description.degree | Programa de Doctorat en Ciències |
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