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Inhibition of VEGF Expression in Cancer Cells and Endothelial Cell Differentiation by Synthetic Stilbene Derivatives
dc.contributor.author | Martí-Centelles, Rosa | |
dc.contributor.author | Cejudo Marín, Rocío | |
dc.contributor.author | Falomir, Eva | |
dc.contributor.author | Murga, Juan | |
dc.contributor.author | Carda, Miguel | |
dc.contributor.author | Marco, J. Alberto | |
dc.date.accessioned | 2014-05-19T10:04:31Z | |
dc.date.available | 2014-05-19T10:04:31Z | |
dc.date.issued | 2013-06-01 | |
dc.identifier.citation | MARTÍ-CENTELLES, Rosa, et al. Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. Bioorganic & medicinal chemistry, 2013, vol. 21, no 11, p. 3010-3015 | ca_CA |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | http://hdl.handle.net/10234/92450 | |
dc.description.abstract | We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine aorta endothelial cells. In addition, it has been confirmed through the reverse transcriptase/polymerase chain reaction experiment that these stilbene derivatives downregulate the expression of the gene related to the production of the angiogenesis factor VEGF in cancer cells. | ca_CA |
dc.format.extent | 6 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Bioorganic & medicinal chemistry, 2013, vol. 21, no 11 | ca_CA |
dc.rights | Copyright © 2013 Elsevier Ltd. All rights reserved. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Angiogenesis | ca_CA |
dc.subject | Antiangiogenic compounds | ca_CA |
dc.subject | Stilbenes | ca_CA |
dc.subject | Resveratrol | ca_CA |
dc.subject | VEGF | ca_CA |
dc.subject | Gene regulation | ca_CA |
dc.subject | Endothelial differentiation | ca_CA |
dc.subject | Anticancer drugs | ca_CA |
dc.title | Inhibition of VEGF Expression in Cancer Cells and Endothelial Cell Differentiation by Synthetic Stilbene Derivatives | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.bmc.2013.03.072 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0968089613002940# | ca_CA |
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