Inhibition of VEGF Expression in Cancer Cells and Endothelial Cell Differentiation by Synthetic Stilbene Derivatives
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comunitat-uji-handle2:10234/7053
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http://dx.doi.org/10.1016/j.bmc.2013.03.072 |
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Title
Inhibition of VEGF Expression in Cancer Cells and Endothelial Cell Differentiation by Synthetic Stilbene DerivativesAuthor (s)
Date
2013-06-01Publisher
ElsevierISSN
0968-0896Bibliographic citation
MARTÍ-CENTELLES, Rosa, et al. Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. Bioorganic & medicinal chemistry, 2013, vol. 21, no 11, p. 3010-3015Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0968089613002940#Subject
Abstract
We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and ... [+]
We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine aorta endothelial cells. In addition, it has been confirmed through the reverse transcriptase/polymerase chain reaction experiment that these stilbene derivatives downregulate the expression of the gene related to the production of the angiogenesis factor VEGF in cancer cells. [-]
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Bioorganic & medicinal chemistry, 2013, vol. 21, no 11Rights
Copyright © 2013 Elsevier Ltd. All rights reserved.
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