Listar QUIO_Articles por autoría "59237f6b-5bb8-410a-9d1f-a6d38b64cb1d"
Mostrando ítems 1-20 de 24
-
Aldol Reactions between L-Erythrulose Derivatives and Chiral α-Amino and α -Fluoro Aldehydes: Competition between Felkin–Anh and Cornforth Transition States
Diaz-Oltra, Santiago; Carda, Miguel; Murga, Juan; Falomir, Eva; Marco, J. Alberto Wiley-Blackwell (2008)Both matched and mismatched diastereoselection have been observed in aldol reactions of a boron enolate of a protected l-erythrulose derivative with several chiral α-fluoro and α-Amino aldehydes. Strict adherence to the ... -
Antiplasmodial and Cytotoxic Activity of Piper Piedecuestanum Trel. and Yunck
Mesa Vanegas, Ana Maria; Toro Suaza, Jhon Fredy; Vásquez Cardona, Ana María; Blair Trujillo, Silvia; Peláez Jaramillo, Carlos; Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Carda, Miguel Academic Journals, New York (2018)ackground and Objective: Plasmodium resistance to antimalarial drugs has expanded and in tensified, making new and effective antimalarial drugs urgently. The objective of this work was the in vitro evaluation of ... -
Chameleonic, Light Harvesting Photonic Gels Based on Orthogonal Molecular Fibrillization
Felip-León, Carles; Diaz-Oltra, Santiago; Galindo, Francisco; Miravet, Juan American Chemical Society (2016-10)The preparation of smart photonic gels composed of two orthogonally self-assembled fibrillar networks is reported. The molecular gelators are a light acceptor derived from 4-amino-1,8-naphthalimide and an acridine-based ... -
Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with Tubulin
Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Redondo Horcajo, Mariano; Fernando Díaz, J.; Barasoain, Isabel; Alberto Marco, J. American Chemical Society (2014-11)We here report the synthesis of a series of 12 hybrid molecules composed of a colchicine moiety and a pironetin analogue fragment. The two fragments are connected through an ester–amide spacer of variable length. The ... -
Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activity
Torijano Gutiérrez, Sandra Adela; Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Wiley Online Library (2014)We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these compounds ... -
Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity
Vilanova Gallén, Concepción; Torijano Gutiérrez, Sandra Adela; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Alberto Marco, J. Elsevier (2014)We here describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment connected through a spacer of variable length which includes a 1,2,3-triazole ring. ... -
Double diastereoselection in anti aldol reactions mediated by dicyclohexylchloroborane between an L-erythrulose derivative and chiral aldehydes
Diaz-Oltra, Santiago; Ruiz, Purificación; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Royal Society of Chemistry (2012)Anti aldol reactions of an L-erythrulose derivative with several α-chiral aldehydes mediated by dicyclohexylboron chloride are examined. Good yields and stereoselectivities are observed. The results are best explained ... -
Freezing Capture of Polymorphic Aggregates of Bolaamphiphilic L-Valine-Based Molecular Hydrogelators
Nebot Carda, Vicent J.; Diaz-Oltra, Santiago; Smets, Johan; Fernández Prieto, Susana; Miravet, Juan; Escuder, Beatriu WILEY-VCH Verlag GmbH & Co. KGaA (2014-05)Nanostructured xerogels have been prepared by the freeze-drying of hydrogels and aggregates formed by bolaamphiphilic l-valine derivatives after aging under different environmental conditions. A wide variety of shapes and ... -
Inhibitory effect of pironetin analogue/colchicine hybrids on the expression of the VEGF, hTERT and c-Myc genes
Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Elsevier (2015-08)A small group of hybrid molecules composed of a colchicine moiety and a pironetin analogue fragment have been investigated for their ability to inhibit the expression of the VEGF, hTERT and c-Myc genes. The VEGF gene is ... -
Self‐Assembled Nanofibrilar Networks: Boosting Hydrogelation Efficiency by Replacement of a Pyridine Moiety by a Quinoline One
Angulo-Pachón, César A.; Diaz-Oltra, Santiago; Ojeda, Juan José; Falomir, Eva; Galindo, Francisco; Miravet, Juan Wiley (2015-08)A new molecular hydrogelator consisting of a L‐Valine derivative with appended quinoline units behaves as a supramolecular superhydrogelator forming gels at such low concentrations as 0.8 mM (0.05% w/w). On the other hand, ... -
Stereoselective synthesis of a C1-C18 fragment of amphidinolides G and H
García Fortanet, Jorge; Formentín, Pilar; Diaz-Oltra, Santiago; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2013-04)A stereoselective synthesis of a C1–C18 segment of the structure of the cytotoxic macrolides amphidinolides G and H is reported. The target compound was retrosynthetically disconnected into three fragments. In the synthetic ... -
Stereoselective Synthesis of the Cytotoxic 14-Membered Macrolide Aspergillide A
Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Murga, Juan; Carda, Miguel; Marco, J. Alberto American Chemical Society (2010)A stereoselective synthesis of the cytotoxic 14-membered macrolide aspergillide A has been performed. The preparation of a cis-2,6-disubstituted tetrahydropyran ring via stereoselective reduction of an intermediate cyclic ... -
Stereoselective synthesis of the cytotoxic macrolide aspergillide B
Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Kneeteman, María N.; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2009)A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic ... -
Study of the effect of polymorphism on the self-assembly and catalytic performance of an L-proline based molecular hydrogelator
Diaz-Oltra, Santiago; Berdugo Gumbau, Cristina; Miravet, Juan; Escuder, Beatriu Royal Society of Chemistry (2015)An exhaustive study of the polymorphism found for aggregates and hydrogels of an L-proline based hydrogelator under different preparation conditions is undertaken. The effect of heating temperature, aging time, ultrasound ... -
Synthesis and Biological Evaluation As Microtubule-Active Agents of Several Tetrahydrofuran and Spiroacetal Derivatives
Carda, Miguel; Murga, Juan; Angulo-Pachón, César A.; García Pla, Jorge; Diaz-Oltra, Santiago; Marco, J. Alberto; Trigili, Chiara; Redondo Horcajo, Mariano; Díaz, J. Fernando; Barasoain, Isabel Bentham Science (2013)The stereoselective preparation of several molecules containing structural fragments of the tetrahydrofuran and spiroacetal type is described. Their degree of cytotoxicity and their interactions with tubulin have been ... -
Synthesis and Biological Evaluation of a-Tubulin-Binding Pironetin Analogues with Enhanced Lipophilicity
Carda, Miguel; Murga, Juan; Falomir, Eva; Diaz-Oltra, Santiago; García Pla, Jorge; Paños Pérez, Julián; Trigili, Chiara; Díaz, J. Fernando; Barasoain, Isabel; Marco, J. Alberto Wiley-VCH Verlag (2013)The preparation of four new lipophilic analogues of the natural pyrone pironetin is described. The nine-carbon side chain of the latter has been replaced in one analogue by a 4-phenylbutyl chain and in the other three ... -
Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring
Paños Pérez, Julián; Diaz-Oltra, Santiago; Sanchez Peris, Maria; García Pla, Jorge; Murga, Juan; Falomir, Eva; Carda, Miguel; Redondo Horcajo, Mariano; Fernando Díaz, J.; Barasoain, Isabel; Alberto Marco, J. Royal Society of Chemistry (2013)The preparation of several new truncated analogues of the natural dihydropyrone pironetin is described. They differ from the natural product mainly in the suppression of some of the alkyl pendants in either the side chain ... -
Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B
Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Wiley (2010-11-09)Total, stereoselective syntheses of the naturally occurring, cytotoxic macrolides aspergillide A and B are described. Olefin metatheses and asymmetric allylations were key steps in the synthetic sequences. Cytotoxicity ... -
Synthesis and leishmanicidal activity of cinnamic acid esters: structure–activity relationship
Otero, Elver; Robledo, Sara M.; Diaz-Oltra, Santiago; Carda, Miguel; Muñoz, Diana; Paños Pérez, Julián; Vélez, Iván D.; Cardona Galeano, Wilson Isidro Springer (2014)Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcohols. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds ... -
Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity
Torijano Gutiérrez, Sandra Adela; Diaz-Oltra, Santiago; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2013-12)We here report the synthesis and biological evaluation of several combretastatin A-4 derivatives alkylated at the phenol hydroxyl group. Some of these derivatives contain an (E)-arylalkene fragment reminiscent of that ...