Antiplasmodial and Cytotoxic Activity of Piper Piedecuestanum Trel. and Yunck
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Otros documentos de la autoría: Mesa Vanegas, Ana Maria; Toro Suaza, Jhon Fredy; Vásquez Cardona, Ana María; Blair Trujillo, Silvia; Peláez Jaramillo, Carlos; Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Carda, Miguel
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INVESTIGACIONMetadatos
Título
Antiplasmodial and Cytotoxic Activity of Piper Piedecuestanum Trel. and YunckAutoría
Fecha de publicación
2018Editor
Academic Journals, New YorkISSN
1819-3455; 2151-7924Cita bibliográfica
Vanegas, Ana Maria Mesa, et al. "Antiplasmodial and Cytotoxic Activity of Piper Piedecuestanum Trel. and Yunck." Research Journal of Medicinal Plants, 2018, vol. 12, núm. 2, p. 57-64Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://scialert.net/abstract/?doi=rjmp.2018.57.64Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
ackground and Objective:
Plasmodium resistance to antimalarial drugs has expanded and in
tensified, making new and effective
antimalarial drugs urgently. The objective of this work was the
in vitro
evaluation ... [+]
ackground and Objective:
Plasmodium resistance to antimalarial drugs has expanded and in
tensified, making new and effective
antimalarial drugs urgently. The objective of this work was the
in vitro
evaluation of antiplasmodial activity of extracts of differen
t polarity
and compounds of the species
P. piedecuestanum
.
Materials and Methods:
The plant materials were obtained through successive
extractions using solvents of different polarity such as hexane (H), dichloromethane (D), ethyl acetate (A) and methanol (M) and
separations techniques for fractionation and isolation of compounds. The antiplasmodial activities of the extracts and compounds were
evaluated by SYBR Green I® method and evaluated the cytotoxicit
y in the cell lines U-937, HUVEC by the MTT method.
Results:
The
antiplasmodial and cytotoxic activity of the extracts of dichloromethane (PPD) and ethyl ac
etate (PPAE) with antiplasmodi
al activity
of IC
50
= 17.93 μg mL
G
1
; IS = 2.093 and IC
50
= 19.5 μg mL
G
1
; IS = 0.791, respectively are reported for the first time. In addition, from
P. piedecuestanum
species were isolation and characterization five metabolites
5,8-Hydroxy-7-methoxyflavone(1), 6,7-dimethoxy-5,8-
dihydroxyflavone(2), 6,7-dimethoxy-5-hydroxyflavone (mosloflavo
ne) (3), 5,6-dihydroxy-7-methoxyflavone (negletein) (4), 5-hydr
oxy-7-
methoxyflavone (5) and a brominated derivative from (5) named 6,8 bromo-5-hydroxy-7-methoxyflavone(7). Compound (1) presented
promising antiplasmodial activity with an IC
50
= 7.325 μg mL
G
1
(25.69 μM); IS
HUVEC
=13.65.
Conclusion:
Chemical analysis of extracts and
compounds from
P. piedecuestanum
spices
will play a central role in the development and modernization o
f an antimalarial herbal
traditional in Colombia. [-]
Publicado en
Research Journal of Medicinal Plants, 2018, vol. 12, núm. 2, p. 57-64Proyecto de investigación
The authors are grateful for the financial support provided by the Colombi an Ministry of Agriculture (No. 009-2007-V7552-38-07), Colciencias through the José de Caldas franchises and the University of AntioquiaDerechos de acceso
info:eu-repo/semantics/openAccess
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