Listar QUIO_Articles por autoría "3896fa5e-4aba-43cd-9e56-384501cb8e7b"
Mostrando ítems 21-29 de 29
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Quantum mechanics/molecular mechanics studies of the mechanism of cysteine protease inhibition by peptidyl-2,3-epoxyketones
Arafet Cruz, Kemel; Ferrer Castillo, Silvia; González, Florenci; Moliner, Vicent Royal Society of Chemistry (2017)Cysteine proteases are the most abundant proteases in parasitic protozoa and they are essential enzymes to the life cycle of several of them, thus becoming attractive therapeutic targets for the development of new ... -
Quantum Mechanics/Molecular Mechanics Studies of the Mechanism of Cysteine Proteases Inhibition by Dipeptidyl Nitroalkenes
Arafet Cruz, Kemel; González, Florenci; Moliner, Vicent Wiley (2020-02-11)In this work a computational study of the mechanism of inhibition of cruzain, rhodesain, and cathepsin L cysteine proteases by the dipeptidyl nitroalkene Cbz‐Phe‐Ala‐CH=CH‐NO2 has been carried out by means of molecular ... -
Radical Mechanism in the Elimination of 2-Arylsulfinyl Esters
Latorre, Antonio; López Martín, Irakusne; Ramírez, Victoria; Rodríguez, Santiago; Izquierdo Ferrer, Javier; González, Florenci; Vicent Barrera, Cristian American Chemical Society (2012-05)The mechanism of the dehydrosulfenylation of 2-arylsulfinyl esters was investigated. The reaction was found to follow a homolytic cleavage mechanism as verified by electrospray ionization tandem mass spectrometry and ... -
Regioselective Opening of Nitroepoxides with Unsymmetrical Diamines
Nosood, Yazdanbakhsh L.; Halimehjani, Azim Ziyaei; González, Florenci American Chemical Society (2018-01)Nitroepoxides are easily transformed into benzodiazepines, tetrahydrobenzodiazepines, imidazopyridines, and N-alkyl tetrahydroquinoxalines by treatment with 2-aminobenzylamines, 2-aminopyridines, and N-alkyl 1,2-diaminobenzenes, ... -
Regioselective ring opening and isomerization reactions of 3,4-epoxyesters catalyzed by boron trifluoride
Rodríguez, Santiago; González, Florenci; Izquierdo Ferrer, Javier American Chemical Society (2011)Efficient ring opening of 3,4-epoxyesters with alcohols to produce 4-alkoxy-3-hydroxyesters and their isomerization into 4-ketoesters using boron trifluoride as the catalyst are presented. Both transformations are simple ... -
Stereoisomerization of β-Hydroxy-α-sulfenyl-γ-butyrolactones Controlled by Two Concomitant 1,4-Type Nonbonded Sulfur−Oxygen Interactions As Analyzed by X-ray Crystallography
González, Florenci; Jain, Amit; Rodríguez, Santiago; Sáez, José A.; Vicent Barrera, Cristian; Peris, Gabriel American Chemical Society (2010)We have synthesized nine β-hydroxy-α-sulfenyl-γ-butyrolactones having different substituents. The syn-anti or syn-syn lactones (or any mixture of both) invariably isomerized into syn-anti/syn-syn lactones in a ratio of ... -
Synthetic studies on the preparation of alanyl epoxysulfones as cathepsin cysteine protease electrophilic traps
Latorre, Antonio; Rodríguez, Santiago; González, Florenci; Florea, Bogdan I.; Overkleeft, Herman S. American Chemical Society (2015-07)A Darzens reaction between tert-butoxycarbonyl alaninal and chloromethyl phenyl sulfone afforded chlorohydrins, which were converted into epoxysulfones by reaction with sodium tert-butoxide. Epoxysulfone 10 and chloroketone ... -
Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes
Bou Iserte, Lledó; Latorre, Antonio; Rodríguez, Santiago; González, Florenci (2019)Aldehydes are easily transformed into vicinal diamines and piperazines through a one-pot procedure including a Darzens reaction and treatment with an amine or diamine and then with a reducing agent. Additionally, quinoxalines ... -
Transcription factors HB21/40/53 trigger inflorescence arrest through abscisic acid accumulation at the end of flowering
Sánchez-Gerschon, Verónica; Martínez-Fernández, Irene; Gonzalez Bermudez, Maria R; De la Hoz Rodríguez, Sergio; González, Florenci; Lozano-Juste, Jorge; Ferrándiz, Cristina; Balanzà, Vicente Oxford University Press (2024-04-26)Flowers, and hence, fruits and seeds, are produced by the activity of the inflorescence meristem after the floral transition. In plants with indeterminate inflorescences, the final number of flowers produced by the ...