Listar PSB_Articles por autoría "dd1b5962-86a0-41c1-be29-1fa66847abe1"
Mostrando ítems 1-12 de 12
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Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Nunes, Eric J.; Randall, Patrick A.; Santerre, Jessica L.; Given, A. B.; Sager, Thomas Nikolaj; Correa, Merce; Salamone, John Elsevier (2010)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from ... -
Dopamine, behavioral economics, and effort
Salamone, John; Correa, Merce; Farrar, Andrew M.; Nunes, Eric J.; Pardo Andrés, Marta Frontiers Research Foundation (2009)There are numerous problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as ... -
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences
Randall, Patrick A.; Pardo Andrés, Marta; Nunes, Eric J.; López Cruz, Laura; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2012)Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task
Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Salamone, John; Estrada, Alexavier; Epling, Brian; Hart, Evan E.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis Springer (2014-02)Rationale. Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of ... -
Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
Farrar, Andrew M.; Segovia, Kristen N.; Randall, Patrick A.; Nunes, Eric J.; Collins, Lyndsey E.; Stopper, Colin M.; Port, Russell G.; Hockemeyer, J.; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2010-04)Nucleus accumbens dopamine (DA) is a critical component of the brain circuitry regulating work output in reinforcement-seeking behavior and effort-related choice behavior. Moreover, there is evidence of an interaction ... -
Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors
Nunes, Eric J.; Randall, Patrick A.; Podurgiel, Samantha J.; Correa, Merce; Salamone, John Elsevier (2013)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Although nucleus accumbens (NAc) DA depletions or antagonism leave aspects of appetite ... -
Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation
Salamone, John; Correa, Merce; Farrar, Andrew M.; Nunes, Eric J.; Collins, Lyndsey E. Future Medicine (2010)Brain dopamine, particularly in the nucleus accumbens, has been implicated in activational aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce the tendency of rats to work for food, and ... -
The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond
Salamone, John; Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Pardo Andrés, Marta Wiley (2012-01)For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the “rewarding” impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic ... -
The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions
Santerre, Jessica L.; Nunes, Eric J.; Kovner, Rotem; Leser, Chelsea E.; Randall, Patrick A.; Collins, Lyndsey E.; López Cruz, Laura; Correa, Merce; Baqi, Younis; Müller, Christa E.; Salamone, John Elsevier (2012)Adenosine A2A and dopamine D2 receptors interact to regulate diverse aspects of ventral and dorsal striatal functions related to motivational and motor processes, and it has been suggested that adenosine A2A antagonists ... -
The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists
Yohn, Samantha E.; Santerre, Jessica L.; Nunes, Eric J.; Kozak, Rouba; Podurgiel, Samantha J.; Correa, Merce; Salamone, John Elsevier (2015)Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry involved in behavioral activation and effort-related processes. Although much is known about the characteristics of ... -
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor
López Cruz, Laura; Podurgiel, Samantha J.; Nunes, Eric J.; Yohn, Samantha E.; Barber, J.; Thompson, A.; Milligan, M.; Lee, Christie A.; Pardo Andrés, Marta; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2013)Tetrabenazine (TBZ) is a reversible inhibitor of vesicular monoamine storage that is used to treat Huntington’s disease. TBZ preferentially depletes striatal dopamine (DA), and patients being treated with TBZ often experience ... -
The VMAT-2 Inhibitor Tetrabenazine Affects EffortRelated Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs
Randall, Patrick A.; Lee, Christie A.; Nunes, Eric J.; Yohn, Samantha E.; Nowak, Victoria; Khan, Bilal; Shah, Priya; Pandit, Saagar; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2014)Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression ...