The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond
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Otros documentos de la autoría: Salamone, John; Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Pardo Andrés, Marta
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http://dx.doi.org/10.1901/jeab.2012.97-125 |
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Título
The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyondFecha de publicación
2012-01Editor
WileyISSN
0022-5002Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://onlinelibrary.wiley.com/doi/10.1901/jeab.2012.97-125/abstractVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the “rewarding” impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic ... [+]
For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the “rewarding” impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic DA are undergoing a substantial conceptual restructuring, with the traditional emphasis on hedonia and primary reward yielding to other concepts and lines of inquiry. The present review is focused upon the involvement of nucleus accumbens DA in effort-related choice behavior. Viewed from the framework of behavioral economics, the effects of accumbens DA depletions and antagonism on food-reinforced behavior are highly dependent upon the work requirements of the instrumental task, and DA-depleted rats show a heightened sensitivity to response costs, especially ratio requirements. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related choice behavior. Rats with accumbens DA depletions or antagonism reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and show increased selection of low reinforcement/low cost options. Nucleus accumbens DA and adenosine interact in the regulation of effort-related functions, and other brain structures (anterior cingulate cortex, amygdala, ventral pallidum) also are involved. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as symptoms such as psychomotor slowing, fatigue or anergia in depression and other neurological disorders. [-]
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Journal of the Experimental Analysis of Behavior, v. 97 (1), p. 125–146Derechos de acceso
Copyright 2012 Society for the Experimental Analysis of Behavior
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