Listar Departament: Psicologia Bàsica, Clínica i Psicobiologia por autoría "9fce0b0f-383f-4840-9777-872cbfe38761"
Mostrando ítems 61-80 de 80
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Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation
Salamone, John; Correa, Merce; Farrar, Andrew M.; Nunes, Eric J.; Collins, Lyndsey E. Future Medicine (2010)Brain dopamine, particularly in the nucleus accumbens, has been implicated in activational aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce the tendency of rats to work for food, and ... -
Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonists
Pardo Andrés, Marta; López Cruz, Laura; San Miguel Segura, Noemí; Salamone, John; Correa, Merce Springer Verlag (2015)Rationale Low doses of dopamine (DA) antagonists and accumbens DA depletions reduce food-reinforced instrumental behavior but do not impair primary food motivation, causing animals to reallocate behavior away from ... -
Sex and age differences in mice models of effort-based decision-making and anergia in depression : the role of dopamine, and cerebral-dopamine-neurotrophic-factor
Matas-Navarro, Paula; Carratalá Ros, Carla; Olivares-García, Régulo; Martínez-Verdú, Andrea; Salamone, John; Correa, Merce Springer Nature (2023-08-18)Mesolimbic dopamine (DA) regulates vigor in motivated behavior. While previous results have mainly been performed in male rodents, the present studies compared CD1 male and female mice in effort-based decision-making tests ... -
Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: Suppression of high effort activity by the serotonin transport inhibitor fluoxetine
Presby, Rose; Rotolo, Renee; Hurley, Erin M.; Ferrigno, Sarah M.; Murphy, Cayla; McMullen, Haley P.; Desai, Pranally A.; Zorda, Emma; Kuperwasser, Felicita B.; Carratalá-Ros, Carla; Correa, Merce; Salamone, John Elsevier (2021)Selective serotonin transport (SERT) inhibitors such as fluoxetine are the most commonly prescribed treatments for depression. Although efficacious for many symptoms of depression, motivational impairments such as psychomotor ... -
Slow phasic changes in nucleus accumbens dopamine release during fixed ratio acquisition: a microdialysis study
Segovia, Kristen N.; Correa, Merce; Salamone, John Elsevier (2011)Nucleus accumbens dopamine (DA) is a critical component of the brain circuitry regulating behavioral output during reinforcement-seeking behavior. Several studies have investigated the characteristics of accumbens DA release ... -
The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond
Salamone, John; Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Pardo Andrés, Marta Wiley (2012-01)For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the “rewarding” impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic ... -
The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures
Yang, Jen-Hau; Presby, Rose; Rotolo, Renee; Quiles, Taina; Okifo, Kevin; Zorda, Emma; Fitch, R. Holly; Correa, Merce; Salamone, John Springer (2020)Rationale Effort-based decision-making tasks allow animals to choose between preferred reinforcers that require high effort to obtain vs. low-effort/low reward options. Mesolimbic dopamine (DA) and related neural systems ... -
The Impact of Caffeine on the Behavioral Effects of Ethanol Related to Abuse and Addiction: A Review of Animal Studies
López Cruz, Laura; Salamone, John; Correa, Merce Mary Ann Liebert, Inc. publishers (2013)The impact of caffeine on the behavioral effects of ethanol, including ethanol consumption and abuse, has become a topic of great interest due to the rise in popularity of the so-called energy drinks. Energy drinks high ... -
The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine
Podurgiel, Samantha J.; Yohn, Samantha E.; Dortche, Kristina; Correa, Merce; Salamone, John Elsevier (2016)Tetrabenazine (TBZ) is prescribed for the treatment of chorea associated with Huntington’s disease. Via inhibition of the vesicular monoamine transporter (VMAT-2), TBZ blocks dopamine (DA) storage and depletes striatal DA; ... -
The monoamine-oxidase B inhibitor deprenyl increases selection of high-effort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treating motivational dysfunctions
Yohn, Samantha E.; Reynolds, Shanika; Tripodi, Guiseppe; Correa, Merce; Salamone, John Elsevier (2018-04)Motivated behaviors often are characterized by a high degree of behavioral activation and work output, and organisms frequently make effort-related decisions based upon cost/benefit analyses. Moreover, people with depression ... -
The mysterious motivational functions of mesolimbic dopamine
Salamone, John; Correa, Merce Cell Press (2012-11)Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance ... -
The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making
Pardo, Marta; Paul, Nicholas E.; Collins-Praino, Lyndsey; Salamone, John; Correa, Merce Elsevier (2020)Considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function. Nonselective adenosine antagonists such as the methylxanthine caffeine as well as selective adenosine ... -
The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions
Santerre, Jessica L.; Nunes, Eric J.; Kovner, Rotem; Leser, Chelsea E.; Randall, Patrick A.; Collins, Lyndsey E.; López Cruz, Laura; Correa, Merce; Baqi, Younis; Müller, Christa E.; Salamone, John Elsevier (2012)Adenosine A2A and dopamine D2 receptors interact to regulate diverse aspects of ventral and dorsal striatal functions related to motivational and motor processes, and it has been suggested that adenosine A2A antagonists ... -
The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding
Rotolo, Renee; Dragacevic, Vladimir; Kalaba, Predrag; Urban, Ernst; Zehl, Martin; Roller, Alexander; Wackerlig, Judith; Langer, Thierry; Pistis, Marco; De Luca, Maria Antonietta; Caria, Francesca; Schwartz, Rebecca; Presby, Rose; Yang, Jen-Hau; Samels, Shanna; Correa, Merce; Lubec, Gert; Salamone, John Frontiers Media (2019-06-28)Animal studies of effort-based choice behavior are being used to model effort-related motivational dysfunctions in humans. With these procedures, animals are offered a choice between high-effort instrumental actions ... -
The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences
Salamone, John; Correa, Merce; Yohn, Samantha E.; López Cruz, Laura; San Miguel Segura, Noemí; Alatorre, Luisa Elsevier (2016)This review paper is focused upon the involvement of mesolimbic dopamine (DA) and related brain systems in effort-based processes. Interference with DA transmission affects instrumental behavior in a manner that interacts ... -
The renaissance of acetaldehyde as a psychoactive compound: decades in the making
Correa, Merce; Acquas, Elio; Salamone, John Frontiers Media (2014-07-22)As with many events in the history of science, the development of the hypothesis that acetaldehyde is a plausible psychoactive substance with specific central effects (not related to its toxic- ity) has not been either ... -
The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists
Yohn, Samantha E.; Santerre, Jessica L.; Nunes, Eric J.; Kozak, Rouba; Podurgiel, Samantha J.; Correa, Merce; Salamone, John Elsevier (2015)Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry involved in behavioral activation and effort-related processes. Although much is known about the characteristics of ... -
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor
López Cruz, Laura; Podurgiel, Samantha J.; Nunes, Eric J.; Yohn, Samantha E.; Barber, J.; Thompson, A.; Milligan, M.; Lee, Christie A.; Pardo Andrés, Marta; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2013)Tetrabenazine (TBZ) is a reversible inhibitor of vesicular monoamine storage that is used to treat Huntington’s disease. TBZ preferentially depletes striatal dopamine (DA), and patients being treated with TBZ often experience ... -
The VMAT-2 Inhibitor Tetrabenazine Affects EffortRelated Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs
Randall, Patrick A.; Lee, Christie A.; Nunes, Eric J.; Yohn, Samantha E.; Nowak, Victoria; Khan, Bilal; Shah, Priya; Pandit, Saagar; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2014)Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression ... -
The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion
Yohn, Samantha E.; Thompson, Christian; Randall, Patrick A.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis; Correa, Merce; Salamone, John Springer Verlag (2015)Rationale Depressed people show effort-related motivational symptoms, such as anergia, retardation, lassitude, and fatigue. Animal tests can model these motivational symptoms, and the present studies characterized the ...