Listar Departament: Enginyeria de Sistemes Industrials i Disseny por autoría "fda577af-1f88-46b6-b833-411ad80a3a66"
Mostrando ítems 1-20 de 20
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A possible use of melatonin in the dental field: Protein adsorption andinvitrocell response on coated titanium
Cerqueira, Andreia; Romero-Gavilán, Francisco J; Araújo-Gomes, Nuno; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Elsevier (2020)Melatonin (MLT) is widely known for regulating the circadian cycles and has been studied for its role in boneregeneration and inflammation. Its application as a coating for dental implants can condition the local ... -
Antibacterial and osteogenic Cu-doped sol-gel coatings for Ti implant functionalization
Romero-Gavilán, Francisco J; Arias-Mainer, Carlos; Cerqueira, Andreia; García-Arnáez, Iñaki; Scalschi, Loredana; Vicedo, Begonya; Azkargorta, Mikel; Elortza, Felix; Gurruchaga, Mariló; Goñi, Isabel; Suay, Julio Wiley (2023) -
Bioactive zinc-doped sol-gel coating modulates protein adsorption patterns and in vitro cell responses
Cerqueira, Andreia; Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Iloro, Ibon; Azkargorta, Mikel; Elortza, Felix; Izquierdo Escrig, Raul; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Elsevier (2020-12-30)Zinc is an essential element with an important role in stimulating the osteogenesis and mineralization and suppressing osteoclast differentiation. In this study, new bioactive ZnCl2-doped sol-gel materials were designed ... -
Characterization of magnesium doped sol-gel biomaterial for bone tissue regeneration: The effect of Mg ion in protein adsorption
Cerqueira, Andreia; Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Izquierdo Escrig, Raul; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Elsevier (2021-06-01)Magnesium is the fourth most abundant element in the human body with a wide battery of functions in the maintenance of normal cell homeostasis. In the bone, this element incorporates in the hydroxyapatite structure and it ... -
Complex effects of Mg-biomaterials on the osteoblast cell machinery: A proteomic study
Cerqueira, Andreia; García-Arnáez, Iñaki; Romero-Gavilán, Francisco J; Azkargorta, Mikel; Elortza, Felix; Martín de Llanos, José Javier; Carda, Carmen; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Elsevier (2022)The cell–biomaterial interface is highly complex; thousands of molecules and many processes participate in its formation. Growing demand for improved biomaterials has highlighted the need to understand the structure and ... -
Correlation between biological responses in vitro and in vivo to Ca-doped sol-gel coatings assessed using proteomic analysis
García-Arnáez, Iñaki; Romero-Gavilán, Francisco J; Cerqueira, Andreia; Elortza, Felix; Azkargorta, Mikel; Muñoz Guzón, Fernando; Mata Roig, Manuel; MARTIN DE LLANO, JOSE JAVIER; Suay, Julio; GURRUCHAGA, MARILO; Goñi, Isabel Elsevier (2022-10-21)Poor correlation between the results of in vitro testing and the subsequent in vivo experiments hinders the design of biomaterials. Thus, new characterisation methods are needed. This study used proteomic and histological ... -
Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes
García-Arnáez, Iñaki; Cerqueira, Andreia; Romero-Gavilán, Francisco J; Elortza, Felix; Azkargorta, Mikel; Iloro, Ibon; Suay, Julio; Goñi, Isabel; GURRUCHAGA, MARILO Elsevier (2022)Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of osteoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate new ... -
Enhancing the correlation between in vitro and in vivo experiments in dental implant osseointegration: investigating the role of Ca ions
Romero-Gavilán, Francisco J; Cerqueira, Andreia; Anitua, Eduardo; Muñoz, Fernando; García-Arnáez, Iñaki; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio; Tejero, Ricardo Royal Society of Chemistry (2024-02-16)This study delves into the osteogenic potential of a calcium-ion modified titanium implant surface, unicCa, employing state-of-the-art proteomics techniques both in vitro (utilizing osteoblasts and macrophage cell cultures) ... -
Evaluation of the inflammatory responses to sol–gel coatingswith distinct biocompatibility levels
Cerqueira, Andreia; Araújo-Gomes, Nuno; Zhang, Yang; van den Beucken, Jeroen; Martínez Ramos, Cristina; ozturan, seda; Izquierdo Escrig, Raul; Muriach, Maria; Romero Cano, Ricard; Baliño, Pablo; Romero-Gavilán, Francisco J John Wiley and Sons (2021-02-20)The immune system plays a crucial role in determining the implantation outcome, and macrophages are in the frontline of the inflammatory processes. Further, cellular oxidative stress resulting from the material recognition ... -
Influence of calcium ion-modified implant surfaces in protein adsorption and implant integration
Anitua, Eduardo; Cerqueira, Andreia; Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Azkagorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio; Tejero, Ricardo Springer (2021-04-21)Calcium (Ca) is a well-known element in bone metabolism and blood coagulation. Here, we investigate the link between the protein adsorption pattern and the in vivo responses of surfaces modified with calcium ions (Ca-ion) ... -
Insight into the antibacterial mechanism of Cu-enriched sol–gel coatings employing proteomics
Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Cerqueira, Andreia; Scalschi, Loredana; Vicedo, Begonya; Villagrasa, Alejandro; Izquierdo, Raúl; Elortza, Felix; Gurruchaga, Mariló; Goñi, Isabel; Suay, Julio Royal Society of Chemistry (2023)Advanced antibacterial biomaterials can help reduce the severe consequences of infections. Using copper compounds is an excellent option to achieve this goal; they offer a combination of regenerative and antimicrobial ... -
Protein adsorption/desorption dynamics on Ca‑enriched titanium surfaces: biological implications
Romero-Gavilán, Francisco J; Cerqueira, Andreia; Anitua, Eduardo; Tejero, Ricardo; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Izquierdo Escrig, Raul; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Springer (2021-08-27)Calcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant ... -
Proteomic analysis of calcium-enriched sol–gel biomaterials
Romero-Gavilán, Francisco J; Gomes, Nuno; Cerqueira, Andreia; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Azkargorta, Mikel; Iloro, Ibon; Elortza, Felix; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Springer (2019-04)Calcium is an element widely used in the development of biomaterials for bone tissue engineering as it plays important roles in bone metabolism and blood coagulation. The Ca ions can condition the microenvironment at the ... -
Proteomic Analysis of Mesenchymal Stem Cells and Monocyte Co-Cultures Exposed to a Bioactive Silica-Based Sol–Gel Coating
Cerqueira, Andreia; Romero-Gavilán, Francisco J; Helmholz, Heike; Azkargorta, Mikel; Elortza, Félix; Gurruchaga, Mariló; Goñi, Isabel; Willumeit-Römer, Regine; Suay, Julio American Chemical Society (2023)New methodologies capable of extensively analyzing the cell-material interactions are necessary to improve current in vitro characterization methods, and proteomics is a viable alternative. Also, many studies are focused ... -
Proteomic evaluation of human osteoblast responses to titanium implants over time
Romero-Gavilán, Francisco J; Cerqueira, Andreia; García-Arnáez, Iñaki; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Wiley (2022-08-30)Titanium is widely used in bone prostheses due to its excellent biocompatibility and osseointegration capacity. To understand the effect of sandblasted acid-etched (SAE) Ti implants on the biological responses of human ... -
Proteomics as a tool to study the osteoimmunomodulatory role of metallic ions in a sol–gel coating
García-Arnáez, Iñaki; Romero-Gavilán, Francisco J; Cerqueira, Andreia; Azkargorta, Mikel; Elortza, Félix; Suay, Julio; Goñi, Isabel; Gurruchaga, Mariló Royal Society of Chemistry (2023)The success of bone implants depends on the osteoimmunomodulatory (OIM) activity of the biomaterials in the interactions with the periimplantary tissues. Many in vitro tests have been conducted to evaluate the osteoimmunology ... -
Sol-gel coatings for metallic prosthesis from methyl-modified alkoxysilanes: balance between protection and bioactivation
Romero-Gavilán, Francisco J; Carlos-Almeida, J.; Cerqueira, Andreia; GURRUCHAGA, MARILO; Goñi, Isabel; Miranda-Salvado, I. M.; Vaz Fernandes, M. H.; Suay, Julio Elsevier (2020)The reported osteogenic properties of the hybrid silica sol-gel materials make these compositions perfect candidates for bone tissue engineering applications. The aim of this study was the synthesis and characterisation ... -
The effect of calcium–magnesium mixtures in sol–gel coatings on bone tissue regeneration
Cerqueira, Andreia; García-Arnáez, Iñaki; Muriach, Maria; Azkargorta, Mikel; Elortza, Felix; Izquierdo, Raúl; Romero-Gavilán, Francisco J; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Royal Society of Chemistry (2022)Calcium and magnesium are two elements essential for bone structure and metabolism. However, their synergistic or competitive effects on bone regeneration are often overlooked during biomaterial development. We examined ... -
The impact of quercetin-coated implants to promote osteointegration
Arias-Mainer, Carlos; Romero-Gavilán, Francisco J; Cerqueira, Andreia; García-Arnáez, Iñaki; Azkargorta, Mikel; Elortza, Felix; Gurruchaga, Mariló; Goñi, Isabel; Suay, Julio Wiley (2023) -
Using osteogenic medium in the in vitro evaluation of bone biomaterials: Artefacts due to a synergistic effect
Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Cerqueira, Andreia; Arias-Mainer, Carlos; Azkargorta, Mikel; Elortza, Felix; Izquierdo, Raúl; Gurruchaga, Mariló; Goñi, Isabel Elsevier (2023)In vitro tests using bone cells to evaluate the osteogenic potential of biomaterials usually employ the osteogenic medium (OM). The lack of correlation frequently reported between in vitro and in vivo studies in bone ...