Protein Ion Channels as Molecular Ratchets. Switchable Current Modulation in Outer Membrane Protein F Porin Induced by Millimolar La3+ Ions
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Scholar |
Otros documentos de la autoría: Verdiá Báguena, Carmen; Queralt-Martín, María; Aguilella, Vicente; Alcaraz, Antonio
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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http://dx.doi.org/10.1021/jp210790r |
Metadatos
Título
Protein Ion Channels as Molecular Ratchets. Switchable Current Modulation in Outer Membrane Protein F Porin Induced by Millimolar La3+ IonsFecha de publicación
2012Editor
American Chemical SocietyISSN
1932-7447Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://pubs.acs.org/doi/abs/10.1021/jp210790rVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The quest for innovative tunable nanodevices has mainly focused on switches that modulate their properties through engineered conformational changes. We propose here an alternative route that takes advantage of the ... [+]
The quest for innovative tunable nanodevices has mainly focused on switches that modulate their properties through engineered conformational changes. We propose here an alternative route that takes advantage of the crucial role that trace elements play in biological nanosystems. To this end, the effect of lanthanum, a high-valence rare-earth metal, known as blocker and modulator of many ion channels, has been studied in a wide, weakly selective biological pore, the bacterial porin outer membrane protein F (OmpF). We show that millimolar concentrations of lanthanum chloride have a dramatic impact on OmpF, reducing the conductance for positive but not for negative applied voltages, thus inducing switchable, reversible ion current rectification. By applying an external wave to this lanthanum-induced diode, we show that the system can consistently perform like a wave rectifier at considerably higher frequencies than previous nanofluidic diodes. This finding may be the starting point to develop molecular ratchets suitable for a variety of engineering applications. [-]
Publicado en
The Journal of Physical Chemistry C, 116, 39Derechos de acceso
Copyright © 2012 American Chemical Society
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