Protein Ion Channels as Molecular Ratchets. Switchable Current Modulation in Outer Membrane Protein F Porin Induced by Millimolar La3+ Ions
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
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http://dx.doi.org/10.1021/jp210790r |
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Title
Protein Ion Channels as Molecular Ratchets. Switchable Current Modulation in Outer Membrane Protein F Porin Induced by Millimolar La3+ IonsDate
2012Publisher
American Chemical SocietyISSN
1932-7447Type
info:eu-repo/semantics/articlePublisher version
http://pubs.acs.org/doi/abs/10.1021/jp210790rVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
The quest for innovative tunable nanodevices has mainly focused on switches that modulate their properties through engineered conformational changes. We propose here an alternative route that takes advantage of the ... [+]
The quest for innovative tunable nanodevices has mainly focused on switches that modulate their properties through engineered conformational changes. We propose here an alternative route that takes advantage of the crucial role that trace elements play in biological nanosystems. To this end, the effect of lanthanum, a high-valence rare-earth metal, known as blocker and modulator of many ion channels, has been studied in a wide, weakly selective biological pore, the bacterial porin outer membrane protein F (OmpF). We show that millimolar concentrations of lanthanum chloride have a dramatic impact on OmpF, reducing the conductance for positive but not for negative applied voltages, thus inducing switchable, reversible ion current rectification. By applying an external wave to this lanthanum-induced diode, we show that the system can consistently perform like a wave rectifier at considerably higher frequencies than previous nanofluidic diodes. This finding may be the starting point to develop molecular ratchets suitable for a variety of engineering applications. [-]
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The Journal of Physical Chemistry C, 116, 39Rights
Copyright © 2012 American Chemical Society
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