CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo
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Other documents of the author: Carrillo-de Sauvage, María Ángeles; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Martín, Eduardo D.; Pérez Vallés, Ana; Gallego Sánchez, José María; Fernández Villalba, Emiliano; Barcia Sr., Carlos; Barcia, Carlos; Herrero Ezquerro, María Trinidad
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadata
Title
CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivoAuthor (s)
Date
2012Publisher
Public Library of ScienceISSN
1932-6203; 1932-6203Type
info:eu-repo/semantics/articlePublisher version
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjou ...Version
info:eu-repo/semantics/publishedVersionAbstract
CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in
the parenchyma is unclear. Imaging of the cell type responsible for this task and details on ... [+]
CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in
the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in
vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the
brain and in three different species. We observe that CCL2+ astrocytes play a part in the infiltration of T-cells in the brain and
our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important
event for lymphocyte extravasation [-]
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PLoS ONE, February, Volume 7 Issue 2 e30762Rights
info:eu-repo/semantics/openAccess
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Except where otherwise noted, this item's license is described as 2012 Carrillo-de Sauvage et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited