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CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo
dc.contributor.author | Carrillo-de Sauvage, María Ángeles | |
dc.contributor.author | Gómez, Aurora | |
dc.contributor.author | Ros Gómez, Carmen María | |
dc.contributor.author | Ros Bernal, Francisco | |
dc.contributor.author | Martín, Eduardo D. | |
dc.contributor.author | Pérez Vallés, Ana | |
dc.contributor.author | Gallego Sánchez, José María | |
dc.contributor.author | Fernández Villalba, Emiliano | |
dc.contributor.author | Barcia Sr., Carlos | |
dc.contributor.author | Barcia, Carlos | |
dc.contributor.author | Herrero Ezquerro, María Trinidad | |
dc.date.accessioned | 2013-05-24T14:46:45Z | |
dc.date.available | 2013-05-24T14:46:45Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10234/64493 | |
dc.description.abstract | CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the brain and in three different species. We observe that CCL2+ astrocytes play a part in the infiltration of T-cells in the brain and our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important event for lymphocyte extravasation | ca_CA |
dc.format.extent | 10 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Public Library of Science | ca_CA |
dc.relation.isPartOf | PLoS ONE, February, Volume 7 Issue 2 e30762 | ca_CA |
dc.rights | 2012 Carrillo-de Sauvage et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | |
dc.title | CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0030762&representation=PDF | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited