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Modeling methods for studying post-translational and transcriptional modifying enzymes
dc.contributor.author | Roca, Maite | |
dc.contributor.author | Aranda, Juan | |
dc.contributor.author | Moliner, Vicent | |
dc.contributor.author | Tuñón, Iñaki | |
dc.date.accessioned | 2013-05-17T17:36:14Z | |
dc.date.available | 2013-05-17T17:36:14Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1367-5931 | |
dc.identifier.uri | http://hdl.handle.net/10234/64034 | |
dc.description.abstract | Biological catalysis is a complex chemical process that involves not only electronic reorganization in the substrate but also the reorganization of the catalyst. This complexity is even larger in the case of post-transcriptional and post-translational modifications which may involve the interaction between two biomacromolecules. However, the development over the past decades of new computational methods and strategies is offering a detailed molecular picture of the catalytic event and a deep understanding of the mechanisms of chemical reactions in biological environments. Here we review the efforts made in the last years to model catalysis in post-transcriptional and post-translational processes. We stress on the advantages and problems of the different computational strategies and their applicability in different cases | ca_CA |
dc.format.extent | 7 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Current Opinion in Chemical Biology, 2012, Volume 16, Issues 5–6 | ca_CA |
dc.rights | Copyright © 2012 Elsevier Ltd. All rights reserved | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.title | Modeling methods for studying post-translational and transcriptional modifying enzymes | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.cbpa.2012.10.014 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S1367593112001032 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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