Modeling methods for studying post-translational and transcriptional modifying enzymes
comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
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http://dx.doi.org/10.1016/j.cbpa.2012.10.014 |
Metadatos
Título
Modeling methods for studying post-translational and transcriptional modifying enzymesFecha de publicación
2012Editor
ElsevierISSN
1367-5931Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S1367593112001032Versión
info:eu-repo/semantics/publishedVersionResumen
Biological catalysis is a complex chemical process that involves not only electronic reorganization in the substrate but also the reorganization of the catalyst. This complexity is even larger in the case of post-tr ... [+]
Biological catalysis is a complex chemical process that involves not only electronic reorganization in the substrate but also the reorganization of the catalyst. This complexity is even larger in the case of post-transcriptional and post-translational modifications which may involve the interaction between two biomacromolecules. However, the development over the past decades of new computational methods and strategies is offering a detailed molecular picture of the catalytic event and a deep understanding of the mechanisms of chemical reactions in biological environments. Here we review the efforts made in the last years to model catalysis in post-transcriptional and post-translational processes. We stress on the advantages and problems of the different computational strategies and their applicability in different cases [-]
Publicado en
Current Opinion in Chemical Biology, 2012, Volume 16, Issues 5–6Derechos de acceso
Copyright © 2012 Elsevier Ltd. All rights reserved
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