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Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules

dc.contributor.authorMarco, J. Alberto
dc.contributor.authorGarcía Pla, Jorge
dc.contributor.authorCarda, Miguel
dc.contributor.authorMurga, Juan
dc.contributor.authorFalomir, Eva
dc.contributor.authorTrigili, Chiara
dc.contributor.authorNotararigo, Sara
dc.contributor.authorDíaz, J. Fernando
dc.contributor.authorBarasoain, Isabel
dc.date.accessioned2012-10-26T07:37:12Z
dc.date.available2012-10-26T07:37:12Z
dc.date.issued2011-05
dc.identifier.urihttp://hdl.handle.net/10234/50159
dc.description.abstractThe preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activitiesca_CA
dc.format.extent8 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfEuropean Journal of Medicinal Chemistryca_CA
dc.rights.urihttp://rightsstatements.org/vocab/CNE/1.0/*
dc.subjectTubulinca_CA
dc.subjectTubulin-active compundca_CA
dc.subjectMicrotubuleca_CA
dc.subjectMicrotubule destabilization;ca_CA
dc.subjectPironetin analogueca_CA
dc.subjectCytotoxicityca_CA
dc.subject.lcshTubulinca_CA
dc.subject.otherTubulinesca_CA
dc.subject.otherMicrotúbulsca_CA
dc.subject.otherCitotoxicitatca_CA
dc.titleDesign and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubulesca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejmech.2011.02.011
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA


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